Abstract

Tumors reprogram pathways of nutrient acquisition and metabolism to meet the bioenergetic, biosynthetic, and redox demands of malignant cells. These reprogrammed activities are now recognized as hallmarks of cancer, and recent work has uncovered remarkable flexibility in the specific pathways activated by tumor cells to support these key functions. In this perspective, we provide a conceptual framework to understand how and why metabolic reprogramming occurs in tumor cells, and the mechanisms linking altered metabolism to tumorigenesis and metastasis. Understanding these concepts will progressively support the development of new strategies to treat human cancer.

Original languageEnglish (US)
Pages (from-to)e1600200
JournalScience advances
Volume2
Issue number5
DOIs
StatePublished - May 1 2016

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Neoplasms
Energy Metabolism
Oxidation-Reduction
Carcinogenesis
Neoplasm Metastasis

Keywords

  • Cancer
  • glycolysis
  • metabolism
  • mitochondria
  • oncogenes
  • ROS

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fundamentals of cancer metabolism. / DeBerardinis, Ralph J.; Chandel, Navdeep S.

In: Science advances, Vol. 2, No. 5, 01.05.2016, p. e1600200.

Research output: Contribution to journalReview article

DeBerardinis, Ralph J. ; Chandel, Navdeep S. / Fundamentals of cancer metabolism. In: Science advances. 2016 ; Vol. 2, No. 5. pp. e1600200.
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