Furosemide-sensitive K+ channel in glioma cells but not neuroblastoma cells in culture

John H. Johnson, Dorothy P. Dunn, Roger N. Rosenberg

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

A furosemide-sensitive, ouabain-insensitive [86Rb+] uptake is described in glioma cells in culture which is dependent upon external Na+, K+, and Cl- concentrations. This transport activity was also inhibited by bumetanide at 100-fold lower concentrations than furosemide. Furosemide-sensitive swelling of glioma cells is demonstrated and this activity is dependent upon external Na+ and K+ in a manner similar to [86Rb+] uptake. This transport activity was not detected in neuroblastoma cells and the possible relevance of these findings to extracellular K+ buffering by glia is discussed.

Original languageEnglish (US)
Pages (from-to)100-105
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume109
Issue number1
DOIs
StatePublished - Nov 16 1982

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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