Abstract
A furosemide-sensitive, ouabain-insensitive [86Rb+] uptake is described in glioma cells in culture which is dependent upon external Na+, K+, and Cl- concentrations. This transport activity was also inhibited by bumetanide at 100-fold lower concentrations than furosemide. Furosemide-sensitive swelling of glioma cells is demonstrated and this activity is dependent upon external Na+ and K+ in a manner similar to [86Rb+] uptake. This transport activity was not detected in neuroblastoma cells and the possible relevance of these findings to extracellular K+ buffering by glia is discussed.
Original language | English (US) |
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Pages (from-to) | 100-105 |
Number of pages | 6 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 109 |
Issue number | 1 |
DOIs | |
State | Published - Nov 16 1982 |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology