Future Biologic Treatments for Perthes Disease

David G. Little, Harry K W Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Standard surgical approaches for Perthes disease consist of nonoperative physical treatments or surgical treatment. Several investigators have been working on a better understanding of the pathophysiology and pathobiology of Perthes disease. Most of the focus has been on antiresorptive treatments. Other treatment avenues, however, include controlling the inflammatory phase of Perthes disease, increasing revascularization of necrotic bone, and anabolic strategies to increase bone formation. This article presents a current pathophysiological model of Perthes disease, reviews experimental strategies in pharmaceutical treatments, and suggests future areas for research.

Original languageEnglish (US)
Pages (from-to)423-427
Number of pages5
JournalOrthopedic Clinics of North America
Volume42
Issue number3
DOIs
StatePublished - Jul 2011

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Legg-Calve-Perthes Disease
Osteogenesis
Research Personnel
Bone and Bones
Research
Pharmaceutical Preparations

Keywords

  • Biologic interventions
  • Experimental strategies
  • Perthes disease

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Future Biologic Treatments for Perthes Disease. / Little, David G.; Kim, Harry K W.

In: Orthopedic Clinics of North America, Vol. 42, No. 3, 07.2011, p. 423-427.

Research output: Contribution to journalArticle

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