GΒ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling

Keqiang Xie, Kevin L. Allen, Sad Kourrich, José Colón-Saez, Mark J. Thomas, Kevin Wickman, Kirill A. Martemyanov

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

The type 5 G protein Β subunit (GΒ5) can form complexes with members of the regulator of G protein signaling 7 (RGS7) family, but its relevance to neuronal G protein signaling is unclear. We found that mouse RGS7-GΒ5 complexes bound to G protein-gated potassium channels and facilitated their functional coupling to GABA B receptors in neurons. Our findings identify a compartmentalization mechanism that is critical for ensuring high temporal resolution of neuronal G protein signaling.

Original languageEnglish (US)
Pages (from-to)661-663
Number of pages3
JournalNature neuroscience
Volume13
Issue number6
DOIs
StatePublished - Jun 1 2010

ASJC Scopus subject areas

  • Neuroscience(all)

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