GΒ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling

Keqiang Xie, Kevin L. Allen, Sad Kourrich, José Colón-Saez, Mark J. Thomas, Kevin Wickman, Kirill A. Martemyanov

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The type 5 G protein Β subunit (GΒ5) can form complexes with members of the regulator of G protein signaling 7 (RGS7) family, but its relevance to neuronal G protein signaling is unclear. We found that mouse RGS7-GΒ5 complexes bound to G protein-gated potassium channels and facilitated their functional coupling to GABA B receptors in neurons. Our findings identify a compartmentalization mechanism that is critical for ensuring high temporal resolution of neuronal G protein signaling.

Original languageEnglish (US)
Pages (from-to)661-663
Number of pages3
JournalNature Neuroscience
Volume13
Issue number6
DOIs
StatePublished - Jun 2010

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RGS Proteins
GTP-Binding Proteins
GTP-Binding Protein Regulators
GABA-B Receptors
Potassium Channels
Protein Subunits
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Xie, K., Allen, K. L., Kourrich, S., Colón-Saez, J., Thomas, M. J., Wickman, K., & Martemyanov, K. A. (2010). GΒ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling. Nature Neuroscience, 13(6), 661-663. https://doi.org/10.1038/nn.2549

GΒ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling. / Xie, Keqiang; Allen, Kevin L.; Kourrich, Sad; Colón-Saez, José; Thomas, Mark J.; Wickman, Kevin; Martemyanov, Kirill A.

In: Nature Neuroscience, Vol. 13, No. 6, 06.2010, p. 661-663.

Research output: Contribution to journalArticle

Xie, K, Allen, KL, Kourrich, S, Colón-Saez, J, Thomas, MJ, Wickman, K & Martemyanov, KA 2010, 'GΒ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling', Nature Neuroscience, vol. 13, no. 6, pp. 661-663. https://doi.org/10.1038/nn.2549
Xie, Keqiang ; Allen, Kevin L. ; Kourrich, Sad ; Colón-Saez, José ; Thomas, Mark J. ; Wickman, Kevin ; Martemyanov, Kirill A. / GΒ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling. In: Nature Neuroscience. 2010 ; Vol. 13, No. 6. pp. 661-663.
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