Abstract
The mammalian target of rapamycin (mTOR) senses upstream stimuli to regulate numerous cellular functions such as metabolism, growth, and autophagy. Increased activation of mTOR complex 1 (mTORC1) is typically observed in human disease and continues to be an important therapeutic target. Understanding the upstream regulators of mTORC1 will provide a crucial link in targeting hyperactivated mTORC1 in human disease. In this mini-review, we will discuss the regulation of mTORC1 by upstream stimuli, with a specific focus on G-protein coupled receptor signaling to mTORC1.
Original language | English (US) |
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Pages (from-to) | 181-190 |
Number of pages | 10 |
Journal | Molecular Pharmacology |
Volume | 101 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1 2022 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology