G-Protein Coupled Receptor Signaling and Mammalian Target of Rapamycin Complex 1 Regulation

Chase H. Melick, Tshering D. Lama-Sherpa, Adna Curukovic, Jenna L. Jewell

Research output: Contribution to journalReview articlepeer-review

Abstract

The mammalian target of rapamycin (mTOR) senses upstream stimuli to regulate numerous cellular functions such as metabolism, growth, and autophagy. Increased activation of mTOR complex 1 (mTORC1) is typically observed in human disease and continues to be an important therapeutic target. Understanding the upstream regulators of mTORC1 will provide a crucial link in targeting hyperactivated mTORC1 in human disease. In this mini-review, we will discuss the regulation of mTORC1 by upstream stimuli, with a specific focus on G-protein coupled receptor signaling to mTORC1.

Original languageEnglish (US)
Pages (from-to)181-190
Number of pages10
JournalMolecular Pharmacology
Volume101
Issue number4
DOIs
StatePublished - Apr 1 2022
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Fingerprint

Dive into the research topics of 'G-Protein Coupled Receptor Signaling and Mammalian Target of Rapamycin Complex 1 Regulation'. Together they form a unique fingerprint.

Cite this