TY - JOUR
T1 - G-protein-coupled receptors, hedgehog signaling and primary cilia
AU - Mukhopadhyay, Saikat
AU - Rohatgi, Rajat
N1 - Funding Information:
Research in our laboratory are funded by an endowed scholarship from UT Southwestern Medical Center and first-time tenure-track faculty recruitment funds from CPRIT (R1220; SM), and the NIH Common Fund , the Pew Foundation , Sontag Foundation and March of Dimes Foundation (RR).
PY - 2014/9
Y1 - 2014/9
N2 - The Hedgehog (Hh) pathway has become an important model to study the cell biology of primary cilia, and reciprocally, the study of ciliary processes provides an opportunity to solve longstanding mysteries in the mechanism of vertebrate Hh signal transduction. The cilium is emerging as an unique compartment for G-protein-coupled receptor (GPCR) signaling in many systems. Two members of the GPCR family, Smoothened and Gpr161, play important roles in the Hh pathway. We review the current understanding of how these proteins may function to regulate Hh signaling and also highlight some of the critical unanswered questions being tackled by the field. Uncovering GPCR-regulated mechanisms important in Hh signaling may provide therapeutic strategies against the Hh pathway that plays important roles in development, regeneration and cancer.
AB - The Hedgehog (Hh) pathway has become an important model to study the cell biology of primary cilia, and reciprocally, the study of ciliary processes provides an opportunity to solve longstanding mysteries in the mechanism of vertebrate Hh signal transduction. The cilium is emerging as an unique compartment for G-protein-coupled receptor (GPCR) signaling in many systems. Two members of the GPCR family, Smoothened and Gpr161, play important roles in the Hh pathway. We review the current understanding of how these proteins may function to regulate Hh signaling and also highlight some of the critical unanswered questions being tackled by the field. Uncovering GPCR-regulated mechanisms important in Hh signaling may provide therapeutic strategies against the Hh pathway that plays important roles in development, regeneration and cancer.
KW - G-protein coupled receptors
KW - Hedgehog
KW - Primary cilia
KW - Protein sinase A
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U2 - 10.1016/j.semcdb.2014.05.002
DO - 10.1016/j.semcdb.2014.05.002
M3 - Review article
C2 - 24845016
AN - SCOPUS:84905566797
SN - 1084-9521
VL - 33
SP - 63
EP - 72
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
ER -