G-protein-coupled receptors, hedgehog signaling and primary cilia

Saikat Mukhopadhyay, Rajat Rohatgi

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

The Hedgehog (Hh) pathway has become an important model to study the cell biology of primary cilia, and reciprocally, the study of ciliary processes provides an opportunity to solve longstanding mysteries in the mechanism of vertebrate Hh signal transduction. The cilium is emerging as an unique compartment for G-protein-coupled receptor (GPCR) signaling in many systems. Two members of the GPCR family, Smoothened and Gpr161, play important roles in the Hh pathway. We review the current understanding of how these proteins may function to regulate Hh signaling and also highlight some of the critical unanswered questions being tackled by the field. Uncovering GPCR-regulated mechanisms important in Hh signaling may provide therapeutic strategies against the Hh pathway that plays important roles in development, regeneration and cancer.

Original languageEnglish (US)
Pages (from-to)63-72
Number of pages10
JournalSeminars in Cell and Developmental Biology
Volume33
DOIs
StatePublished - 2014

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Hedgehogs
Cilia
G-Protein-Coupled Receptors
Cell Biology
Vertebrates
Regeneration
Signal Transduction
Neoplasms
Proteins

Keywords

  • G-protein coupled receptors
  • Hedgehog
  • Primary cilia
  • Protein sinase A

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology
  • Medicine(all)

Cite this

G-protein-coupled receptors, hedgehog signaling and primary cilia. / Mukhopadhyay, Saikat; Rohatgi, Rajat.

In: Seminars in Cell and Developmental Biology, Vol. 33, 2014, p. 63-72.

Research output: Contribution to journalArticle

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