G protein involvement in receptor-effector coupling

P. J. Casey, A. G. Gilman

Research output: Contribution to journalArticle

390 Citations (Scopus)

Abstract

The recent plethora of information on G proteins has suggested that they play a major role in signaling processes. The use of bacterial toxins, GTP analogs, specific antisera, and oligonucleotide probes has revealed that members or close relatives of the family exist in such primitive organisms as Saccharomyces and Dictyostelium, speaking to a high degree of conservation of these proteins during evolution. The tools of the molecular biologist and structural biochemist will soon allow a more detailed examination of the crucial protein-ligand and protein-protein interactions required for G protein action. The alliance of all of these disciplines will facilitate investigation of G protein-linked signaling processes and of possible pathological disturbances therein.

Original languageEnglish (US)
Pages (from-to)2577-2580
Number of pages4
JournalJournal of Biological Chemistry
Volume263
Issue number6
StatePublished - 1988

Fingerprint

GTP-Binding Proteins
Proteins
Bacterial Toxins
Saccharomyces
Dictyostelium
Oligonucleotide Probes
Pathologic Processes
Guanosine Triphosphate
Immune Sera
Conservation
Ligands

ASJC Scopus subject areas

  • Biochemistry

Cite this

Casey, P. J., & Gilman, A. G. (1988). G protein involvement in receptor-effector coupling. Journal of Biological Chemistry, 263(6), 2577-2580.

G protein involvement in receptor-effector coupling. / Casey, P. J.; Gilman, A. G.

In: Journal of Biological Chemistry, Vol. 263, No. 6, 1988, p. 2577-2580.

Research output: Contribution to journalArticle

Casey, PJ & Gilman, AG 1988, 'G protein involvement in receptor-effector coupling', Journal of Biological Chemistry, vol. 263, no. 6, pp. 2577-2580.
Casey, P. J. ; Gilman, A. G. / G protein involvement in receptor-effector coupling. In: Journal of Biological Chemistry. 1988 ; Vol. 263, No. 6. pp. 2577-2580.
@article{b0df4d5938f24e9fbf5903c38031bfa5,
title = "G protein involvement in receptor-effector coupling",
abstract = "The recent plethora of information on G proteins has suggested that they play a major role in signaling processes. The use of bacterial toxins, GTP analogs, specific antisera, and oligonucleotide probes has revealed that members or close relatives of the family exist in such primitive organisms as Saccharomyces and Dictyostelium, speaking to a high degree of conservation of these proteins during evolution. The tools of the molecular biologist and structural biochemist will soon allow a more detailed examination of the crucial protein-ligand and protein-protein interactions required for G protein action. The alliance of all of these disciplines will facilitate investigation of G protein-linked signaling processes and of possible pathological disturbances therein.",
author = "Casey, {P. J.} and Gilman, {A. G.}",
year = "1988",
language = "English (US)",
volume = "263",
pages = "2577--2580",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "6",

}

TY - JOUR

T1 - G protein involvement in receptor-effector coupling

AU - Casey, P. J.

AU - Gilman, A. G.

PY - 1988

Y1 - 1988

N2 - The recent plethora of information on G proteins has suggested that they play a major role in signaling processes. The use of bacterial toxins, GTP analogs, specific antisera, and oligonucleotide probes has revealed that members or close relatives of the family exist in such primitive organisms as Saccharomyces and Dictyostelium, speaking to a high degree of conservation of these proteins during evolution. The tools of the molecular biologist and structural biochemist will soon allow a more detailed examination of the crucial protein-ligand and protein-protein interactions required for G protein action. The alliance of all of these disciplines will facilitate investigation of G protein-linked signaling processes and of possible pathological disturbances therein.

AB - The recent plethora of information on G proteins has suggested that they play a major role in signaling processes. The use of bacterial toxins, GTP analogs, specific antisera, and oligonucleotide probes has revealed that members or close relatives of the family exist in such primitive organisms as Saccharomyces and Dictyostelium, speaking to a high degree of conservation of these proteins during evolution. The tools of the molecular biologist and structural biochemist will soon allow a more detailed examination of the crucial protein-ligand and protein-protein interactions required for G protein action. The alliance of all of these disciplines will facilitate investigation of G protein-linked signaling processes and of possible pathological disturbances therein.

UR - http://www.scopus.com/inward/record.url?scp=0023867394&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023867394&partnerID=8YFLogxK

M3 - Article

VL - 263

SP - 2577

EP - 2580

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 6

ER -