G protein involvement in receptor-effector coupling

P. J. Casey, A. G. Gilman

Research output: Contribution to journalReview articlepeer-review

409 Scopus citations


The recent plethora of information on G proteins has suggested that they play a major role in signaling processes. The use of bacterial toxins, GTP analogs, specific antisera, and oligonucleotide probes has revealed that members or close relatives of the family exist in such primitive organisms as Saccharomyces and Dictyostelium, speaking to a high degree of conservation of these proteins during evolution. The tools of the molecular biologist and structural biochemist will soon allow a more detailed examination of the crucial protein-ligand and protein-protein interactions required for G protein action. The alliance of all of these disciplines will facilitate investigation of G protein-linked signaling processes and of possible pathological disturbances therein.

Original languageEnglish (US)
Pages (from-to)2577-2580
Number of pages4
JournalJournal of Biological Chemistry
Issue number6
StatePublished - 1988

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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