G proteins

John R. Hepler, Alfred G. Gilman

Research output: Contribution to journalArticle

883 Scopus citations


The family of heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) serves an essential role in transducing receptor-generated signals across the plasma membrane. Recent findings reveal unexpected functional roles for individual G protein subunits. Thus, GTP-binding α-subunits and the βγ-subunit complex can influence the activity of effector molecules independently or simultaneously, either synergistically or in opposition, to elicit a complex constellation of cellular events.

Original languageEnglish (US)
Pages (from-to)383-387
Number of pages5
JournalTrends in Biochemical Sciences
Issue number10
StatePublished - Oct 1992

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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    Hepler, J. R., & Gilman, A. G. (1992). G proteins. Trends in Biochemical Sciences, 17(10), 383-387. https://doi.org/10.1016/0968-0004(92)90005-T