G proteins

John R. Hepler, Alfred G. Gilman

Research output: Contribution to journalArticle

874 Citations (Scopus)

Abstract

The family of heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) serves an essential role in transducing receptor-generated signals across the plasma membrane. Recent findings reveal unexpected functional roles for individual G protein subunits. Thus, GTP-binding α-subunits and the βγ-subunit complex can influence the activity of effector molecules independently or simultaneously, either synergistically or in opposition, to elicit a complex constellation of cellular events.

Original languageEnglish (US)
Pages (from-to)383-387
Number of pages5
JournalTrends in Biochemical Sciences
Volume17
Issue number10
DOIs
StatePublished - 1992

Fingerprint

Guanine Nucleotides
GTP-Binding Proteins
Carrier Proteins
Protein Subunits
Cell membranes
Guanosine Triphosphate
Proteins
Cell Membrane
Molecules

ASJC Scopus subject areas

  • Biochemistry

Cite this

Hepler, J. R., & Gilman, A. G. (1992). G proteins. Trends in Biochemical Sciences, 17(10), 383-387. https://doi.org/10.1016/0968-0004(92)90005-T

G proteins. / Hepler, John R.; Gilman, Alfred G.

In: Trends in Biochemical Sciences, Vol. 17, No. 10, 1992, p. 383-387.

Research output: Contribution to journalArticle

Hepler, JR & Gilman, AG 1992, 'G proteins', Trends in Biochemical Sciences, vol. 17, no. 10, pp. 383-387. https://doi.org/10.1016/0968-0004(92)90005-T
Hepler, John R. ; Gilman, Alfred G. / G proteins. In: Trends in Biochemical Sciences. 1992 ; Vol. 17, No. 10. pp. 383-387.
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