G proteins, chemosensory perception, and the C. elegans genome project: An attractive story

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Heterotrimeric G proteins, consisting of α, β, and γ subunits, couple ligand-bound seven transmembrane domain receptors to the regulation of effector proteins and production of intracellular second messengers. G protein signaling mediates the perception of environmental cues in all higher eukaryotic organisms, including yeast, Dictyostelium, plants, and animals. The nematode Caenorhabditis elegans is the first animal to have complete descriptions of its cellular anatomy, cell lineage, neuronal wiring diagram, and genomic sequence. In a recent paper, Jansen et al. used sequence searches of the C. elegans genome database to identify all heterotrimeric G protein genes (20 Gα, 2 Gβ, 2 Gγ). C. elegans encodes one ortholog of each of the four Gα classes found in metazoans and 16 new Gα genes. The orthologous genes are widely expressed, whereas 14 of the divergent Gα genes are almost exclusively expressed in sensory neurons where they may regulate perception and chemotaxis.

Original languageEnglish (US)
Pages (from-to)713-717
Number of pages5
JournalBioEssays
Volume21
Issue number9
StatePublished - Sep 1999

Fingerprint

G-proteins
GTP-Binding Proteins
Caenorhabditis elegans
Genes
Genome
Heterotrimeric GTP-Binding Proteins
genome
genes
Dictyostelium
Animals
sensory neurons
second messengers
chemotaxis
Protein Subunits
Second Messenger Systems
Cell Lineage
Sensory Receptor Cells
Chemotaxis
Cues
Electric wiring

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

G proteins, chemosensory perception, and the C. elegans genome project : An attractive story. / Wilkie, Thomas M.

In: BioEssays, Vol. 21, No. 9, 09.1999, p. 713-717.

Research output: Contribution to journalArticle

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