@article{5f837fa96b8a48208270a544315666a1,
title = "GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI",
abstract = "The human anterior cingulate cortex (ACC) is part of the default-mode network that shows predominant negative blood oxygen level-dependent (BOLD) responses in functional magnetic resonance imaging (fMRI). We combined fMRI during emotional processing and resting-state magnetic resonance spectroscopy measurements and observed that the concentration of GABA in the ACC specifically correlated with the amount of negative BOLD responses in the very same region. Our findings show that default-mode network negative BOLD responses during emotions are mediated by GABA.",
author = "Georg Northoff and Martin Walter and Schulte, {Rolf F.} and Johannes Beck and Ulrike Dydak and Anke Henning and Heinz Boeker and Simone Grimm and Peter Boesiger",
note = "Funding Information: We acknowledge the contribution by C. Matthi{\"a}who helped in data transfer and made some suggestions to the discussion. The study was supported by a Heisenberg grant from the German Research Foundation (DFG, 304/4-1 to G.N.), the Swiss National Research Foundation (3100A0-100830) to G.N., Funding Information: P.B. and H.B., a grant from the Research Foundation of the University of Zurich, Organon Switzerland to G.N. and H.B., a grant from the Swiss Federal Institute of Technology Zurich (SEP) and Philips Medical Systems, Best, NL, to P.B., and a grant from the Salus Foundation and the Hope for Depression Research Foundation (HDRF) to G.N.",
year = "2007",
month = dec,
doi = "10.1038/nn2001",
language = "English (US)",
volume = "10",
pages = "1515--1517",
journal = "Nature neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "12",
}