Cortical spreading depression (CSD) is an intense depolarization wave implicated in the pathophysiology of brain injury states and migraine aura. As Ca v 2.1 channels modulate CSD susceptibility, we tested gabapentin, which inhibits Ca v 2.1 through high-affinity binding to its α 2 subunit, on CSD susceptibility in anesthetized rats. Gabapentin, 100 or 200 mg/kg, elevated the electrical threshold for CSD and diminished recurrent CSDs evoked by topical KCl, when administered 1 hour before testing. With its favorable safety and tolerability profile, gabapentin may have a role in suppression of injury depolarizations in stroke, intracranial hemorrhage, and traumatic brain injury.
- spreading depression
ASJC Scopus subject areas
- Clinical Neurology
- Cardiology and Cardiovascular Medicine