Gabapentin suppresses cortical spreading depression susceptibility

Ulrike Hoffmann, Ergin Dileköz, Chiho Kudo, Cenk Ayata

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Cortical spreading depression (CSD) is an intense depolarization wave implicated in the pathophysiology of brain injury states and migraine aura. As Ca v 2.1 channels modulate CSD susceptibility, we tested gabapentin, which inhibits Ca v 2.1 through high-affinity binding to its α 2 subunit, on CSD susceptibility in anesthetized rats. Gabapentin, 100 or 200 mg/kg, elevated the electrical threshold for CSD and diminished recurrent CSDs evoked by topical KCl, when administered 1 hour before testing. With its favorable safety and tolerability profile, gabapentin may have a role in suppression of injury depolarizations in stroke, intracranial hemorrhage, and traumatic brain injury.

Original languageEnglish (US)
Pages (from-to)1588-1592
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Volume30
Issue number9
DOIs
StatePublished - Sep 2010
Externally publishedYes

Keywords

  • cortex
  • electrophysiology
  • gabapentin
  • rat
  • spreading depression

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Gabapentin suppresses cortical spreading depression susceptibility'. Together they form a unique fingerprint.

Cite this