Gadolinium-hydrogel-lipid hybrid nanoparticles provide 'off-on-off' MRI signals for non-invasive thermometry

Adam J. Shuhendler, Claudia R. Gordijo, Robert Staruch, Wendy Oakden, Greg Stanisz, Rajiv Chopra, Xiao Yu Wu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Novel metal-chelating temperature-responsive ultrafine hydrogel nanoparticles were synthesized and loaded into a solid lipid nanoparticle carrier with various melting points. The temperature sensitive contrast agent was engineered with two consecutive 'off-on' and 'on-off thermal transitions, which delimit a window within which thermotherapy can be applied. An 'off-on' step transition in contrast enhancement was detected at the melting point of the lipid matrix and an 'on-off step transition is present at the lower critical solution temperature (LCST) of the copolymer hydrogel. A single composite gadolinium-hydrogel-lipid hybrid nanoparticle (Gd-HLN), as formulated here, can thus serve to indicate the onset of non-ablative thermotherapy (42-43°C) and to delineate the transition from non-ablative to ablative temperatures (>55°C). Since both the melting point of the lipid matrix and the LCST of the hydrogel are tunable in terms of temperature of phase transition, the intelligent multiparticle relaxation-enhancing system can be engineered to designate the temperature window specific to the goal of the individual thermotherapy.

Original languageEnglish (US)
Title of host publicationBiological Imaging and Sensing Using Nanoparticle Assemblies
Pages66-72
Number of pages7
StatePublished - Oct 15 2010
Event2009 MRS Fall Meeting - Boston, MA, United States
Duration: Nov 30 2009Dec 4 2009

Publication series

NameMaterials Research Society Symposium Proceedings
Volume1241
ISSN (Print)0272-9172

Other

Other2009 MRS Fall Meeting
CountryUnited States
CityBoston, MA
Period11/30/0912/4/09

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ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Shuhendler, A. J., Gordijo, C. R., Staruch, R., Oakden, W., Stanisz, G., Chopra, R., & Wu, X. Y. (2010). Gadolinium-hydrogel-lipid hybrid nanoparticles provide 'off-on-off' MRI signals for non-invasive thermometry. In Biological Imaging and Sensing Using Nanoparticle Assemblies (pp. 66-72). (Materials Research Society Symposium Proceedings; Vol. 1241).