Gaining a foothold: How HIV avoids innate immune recognition

Nan Yan, Judy Lieberman

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

During the first week after sexual exposure to HIV, HIV infection does not appear to trigger a strong innate immune response. Here we describe some recent studies that show that HIV may avoid triggering antiviral innate immune responses by not replicating efficiently in dendritic cells and by avoiding detection in infected CD4 T cells and macrophages by harnessing a host cytoplasmic DNase TREX1 to digest nonproductive HIV reverse transcripts.

Original languageEnglish (US)
Pages (from-to)21-28
Number of pages8
JournalCurrent Opinion in Immunology
Volume23
Issue number1
DOIs
StatePublished - Feb 2011

Fingerprint

HIV
Innate Immunity
Deoxyribonucleases
Dendritic Cells
HIV Infections
Antiviral Agents
Macrophages
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Gaining a foothold : How HIV avoids innate immune recognition. / Yan, Nan; Lieberman, Judy.

In: Current Opinion in Immunology, Vol. 23, No. 1, 02.2011, p. 21-28.

Research output: Contribution to journalArticle

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