Gaining a foothold: How HIV avoids innate immune recognition

Nan Yan, Judy Lieberman

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

During the first week after sexual exposure to HIV, HIV infection does not appear to trigger a strong innate immune response. Here we describe some recent studies that show that HIV may avoid triggering antiviral innate immune responses by not replicating efficiently in dendritic cells and by avoiding detection in infected CD4 T cells and macrophages by harnessing a host cytoplasmic DNase TREX1 to digest nonproductive HIV reverse transcripts.

Original languageEnglish (US)
Pages (from-to)21-28
Number of pages8
JournalCurrent Opinion in Immunology
Volume23
Issue number1
DOIs
StatePublished - Feb 2011

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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