TY - JOUR
T1 - Galactosyltransferase II in Detection of Pancreatic Cancer
AU - Cebul, Randall D.
AU - Sattin, Richard W.
AU - Podolsky, Daniel K.
AU - Isselbacher, Kurt J.
PY - 1981/9/24
Y1 - 1981/9/24
N2 - To the Editor: Podolsky et al. (May 28 issue),1 in evaluating test batteries that include galactosyltransferase isoenzyme II (GT-II) with one of the other recommended tests, have not specifically considered previously described principles of parallel-test use. When two tests used in parallel are being considered, the criterion for a positive battery may be either that both tests' results must be abnormal or that either test's results may be abnormal. The first criterion improves the battery's aggregate specificity but sacrifices its sensitivity, whereas the more liberal second criterion enhances sensitivity at the expense of specificity.2 , 3 The authors chose the “either test.
AB - To the Editor: Podolsky et al. (May 28 issue),1 in evaluating test batteries that include galactosyltransferase isoenzyme II (GT-II) with one of the other recommended tests, have not specifically considered previously described principles of parallel-test use. When two tests used in parallel are being considered, the criterion for a positive battery may be either that both tests' results must be abnormal or that either test's results may be abnormal. The first criterion improves the battery's aggregate specificity but sacrifices its sensitivity, whereas the more liberal second criterion enhances sensitivity at the expense of specificity.2 , 3 The authors chose the “either test.
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U2 - 10.1056/NEJM198109243051317
DO - 10.1056/NEJM198109243051317
M3 - Letter
C2 - 6790994
AN - SCOPUS:0019887503
SN - 0028-4793
VL - 305
SP - 766
EP - 767
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 13
ER -