Gallbladder and urinary tract precipitations associated with ceftriaxone therapy in children: A prospective study

Ceyda Acun, L. Oktay Erdem, Ayhan Söǧüt, C. Zuhal Erdem, Nazan Tomaç, Sadi Gündoǧdu, Şerafettin ̧ Çavuldak

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15 Citations (Scopus)

Abstract

The incidence and outcome of gallbladder and urinary tract complications in children receiving ceftriaxone therapy were evaluated prospectively. The subjects were given intravenous ceftriaxone, 100 mg/kg/day, in two divided doses infused over 20-30-minute periods, for 5-14 days. Serial abdominal ultrasonography revealed gallbladder and urinary tract precipitations in five of 35 children, three of whom had gallbladder pseudolithiasis, one gallbladder sludge and one gallbladder pseudolithiasis and urinary bladder sludge. The children who had gallbladder sludge and gallbladder pseudolithiasis with urinary bladder sludge had abdominal pain, nausea and vomiting. Three children remained symptom-free. The gallbladder precipitations were found after 4-9 days of ceftriaxone therapy, and resolved completely 7-19 days after the end of treatment. The urinary tract precipitation was found on the 5th day after cessation of ceftriaxone therapy and resolved 7 days later. Ceftriaxone-associated gallbladder pseudolithiasis, gallbladder sludge and urinary bladder sludge usually resolve spontaneously and physicians should be aware of these complications so as to avoid unnecessary therapeutic procedures.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
JournalAnnals of Tropical Paediatrics
Volume24
Issue number1
DOIs
StatePublished - Mar 1 2004

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Ceftriaxone
Gallbladder
Urinary Tract
Prospective Studies
Sewage
Therapeutics
Urinary Bladder
Unnecessary Procedures
Nausea
Abdominal Pain
Vomiting
Ultrasonography
Physicians

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Gallbladder and urinary tract precipitations associated with ceftriaxone therapy in children : A prospective study. / Acun, Ceyda; Erdem, L. Oktay; Söǧüt, Ayhan; Erdem, C. Zuhal; Tomaç, Nazan; Gündoǧdu, Sadi; Çavuldak, Şerafettin ̧.

In: Annals of Tropical Paediatrics, Vol. 24, No. 1, 01.03.2004, p. 25-31.

Research output: Contribution to journalArticle

Acun, Ceyda ; Erdem, L. Oktay ; Söǧüt, Ayhan ; Erdem, C. Zuhal ; Tomaç, Nazan ; Gündoǧdu, Sadi ; Çavuldak, Şerafettin ̧. / Gallbladder and urinary tract precipitations associated with ceftriaxone therapy in children : A prospective study. In: Annals of Tropical Paediatrics. 2004 ; Vol. 24, No. 1. pp. 25-31.
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