Gallstone disease is associated with arterial stiffness progression

Kai Jing Yu; Ji Rong Zhang; Ying Li; Xiaoyi Huang; Tiemin Liu; Chuanfu Li; Rui Tao Wang

doi:10.1038/hr.2016.109

Gallstone disease is associated with arterial stiffness progression

Kai Jing Yu, Ji Rong Zhang, Ying Li, Xiaoyi Huang, Tiemin Liu, Chuanfu Li, Rui Tao Wang

Internal Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Gallstones have been linked to dyslipidemia, metabolic syndrome and cardiovascular disease. Arterial stiffness is an indicator of subclinical atherosclerosis. The aim of this study was to prospectively examine the relationship between gallstone disease and arterial stiffness progression in 347 men and 454 women. These subjects were followed for 7 years. Arterial stiffness progression was measured based on increases in brachial-ankle pulse wave velocity. Changes in brachial-ankle pulse wave velocity during the study period were significantly greater in patients with gallstones than in subjects without gallstones. After adjusting for multiple risk factors, gallstone disease was found to be a significant and independent predictor of brachial-ankle pulse wave velocity progression (β=0.189; P<0.001). In conclusion, gallstone disease is an independent predictor of arterial stiffness progression, even after adjusting for other cardiovascular risk factors.

Original language	English (US)
Pages (from-to)	31-34
Number of pages	4
Journal	Hypertension Research
Volume	40
Issue number	1
DOIs	https://doi.org/10.1038/hr.2016.109
State	Published - Jan 1 2017

Keywords

Arterial stiffness
Brachial-ankle pulse wave velocity
Gallstones

ASJC Scopus subject areas

Internal Medicine
Physiology
Cardiology and Cardiovascular Medicine

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10.1038/hr.2016.109

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title = "Gallstone disease is associated with arterial stiffness progression",

abstract = "Gallstones have been linked to dyslipidemia, metabolic syndrome and cardiovascular disease. Arterial stiffness is an indicator of subclinical atherosclerosis. The aim of this study was to prospectively examine the relationship between gallstone disease and arterial stiffness progression in 347 men and 454 women. These subjects were followed for 7 years. Arterial stiffness progression was measured based on increases in brachial-ankle pulse wave velocity. Changes in brachial-ankle pulse wave velocity during the study period were significantly greater in patients with gallstones than in subjects without gallstones. After adjusting for multiple risk factors, gallstone disease was found to be a significant and independent predictor of brachial-ankle pulse wave velocity progression (β=0.189; P<0.001). In conclusion, gallstone disease is an independent predictor of arterial stiffness progression, even after adjusting for other cardiovascular risk factors.",

keywords = "Arterial stiffness, Brachial-ankle pulse wave velocity, Gallstones",

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AU - Yu, Kai Jing

AU - Zhang, Ji Rong

AU - Li, Ying

AU - Huang, Xiaoyi

AU - Liu, Tiemin

AU - Li, Chuanfu

AU - Wang, Rui Tao

PY - 2017/1/1

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N2 - Gallstones have been linked to dyslipidemia, metabolic syndrome and cardiovascular disease. Arterial stiffness is an indicator of subclinical atherosclerosis. The aim of this study was to prospectively examine the relationship between gallstone disease and arterial stiffness progression in 347 men and 454 women. These subjects were followed for 7 years. Arterial stiffness progression was measured based on increases in brachial-ankle pulse wave velocity. Changes in brachial-ankle pulse wave velocity during the study period were significantly greater in patients with gallstones than in subjects without gallstones. After adjusting for multiple risk factors, gallstone disease was found to be a significant and independent predictor of brachial-ankle pulse wave velocity progression (β=0.189; P<0.001). In conclusion, gallstone disease is an independent predictor of arterial stiffness progression, even after adjusting for other cardiovascular risk factors.

AB - Gallstones have been linked to dyslipidemia, metabolic syndrome and cardiovascular disease. Arterial stiffness is an indicator of subclinical atherosclerosis. The aim of this study was to prospectively examine the relationship between gallstone disease and arterial stiffness progression in 347 men and 454 women. These subjects were followed for 7 years. Arterial stiffness progression was measured based on increases in brachial-ankle pulse wave velocity. Changes in brachial-ankle pulse wave velocity during the study period were significantly greater in patients with gallstones than in subjects without gallstones. After adjusting for multiple risk factors, gallstone disease was found to be a significant and independent predictor of brachial-ankle pulse wave velocity progression (β=0.189; P<0.001). In conclusion, gallstone disease is an independent predictor of arterial stiffness progression, even after adjusting for other cardiovascular risk factors.

KW - Arterial stiffness

KW - Brachial-ankle pulse wave velocity

KW - Gallstones

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Gallstone disease is associated with arterial stiffness progression

Abstract

Keywords

ASJC Scopus subject areas

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