Gamma frequency-range abnormalities to auditory stimulation in schizophrenia

Jun Soo Kwon, Brian F. O'Donnell, Gene V. Wallenstein, Robert W. Greene, Yoshio Hirayasu, Paul G. Nestor, Michael E. Hasselmo, Geoffrey F. Potts, Martha E. Shenton, Robert W. McCarley

Research output: Contribution to journalArticle

382 Citations (Scopus)

Abstract

Background: Basic science studies at the neuronal systems level have indicated that gamma-range (30-50 Hz) neural synchronization may be a key mechanism of information processing in neural networks, reflecting integration of various features of an object. Furthermore, gamma-range synchronization is thought to depend on the glutamatergically mediated interplay between excitatory projection neurons and inhibitory neurons utilizing γ-aminobutyric acid (GABA), which postmortem studies suggest may be abnormal in schizophrenia. We therefore tested whether auditory neural networks in patients with schizophrenia could support gamma-range synchronization. Methods: Synchronization of the electroencephalogram (EEG) to different rates (20-40 Hz) of auditory stimulation was recorded from 15 patients with schizophrenia and 15 sexy, age-, and handedness-matched control subjects. The EEG power at each stimulation frequency was compared between groups. The time course of the phase relationship between each stimulus and EEG peak was also evaluated for gamma-range (40 Hz) stimulation. Results: Schizophrenic patients showed reduced EEG power at 40 Hz, but not at lower frequencies of stimulation. In addition, schizophrenic patients showed delayed onset of phase synchronization and delayed desynchronization to the click train. Conclusions: These data provide new information on selective deficits in early-stage sensory processing in schizophrenia, a failure to support the entrainment of intrinsic gamma-frequency oscillators. The reduced EEG power at 40 Hz in schizophrenic patients may reflect a dysfunction of the recurrent inhibitory drive on auditory neural networks.

Original languageEnglish (US)
Pages (from-to)1001-1005
Number of pages5
JournalArchives of General Psychiatry
Volume56
Issue number11
DOIs
StatePublished - Nov 1999

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Acoustic Stimulation
Electroencephalography
Schizophrenia
Aminobutyrates
Neurons
Functional Laterality
Automatic Data Processing
gamma-Aminobutyric Acid
Power (Psychology)

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Kwon, J. S., O'Donnell, B. F., Wallenstein, G. V., Greene, R. W., Hirayasu, Y., Nestor, P. G., ... McCarley, R. W. (1999). Gamma frequency-range abnormalities to auditory stimulation in schizophrenia. Archives of General Psychiatry, 56(11), 1001-1005. https://doi.org/10.1001/archpsyc.56.11.1001

Gamma frequency-range abnormalities to auditory stimulation in schizophrenia. / Kwon, Jun Soo; O'Donnell, Brian F.; Wallenstein, Gene V.; Greene, Robert W.; Hirayasu, Yoshio; Nestor, Paul G.; Hasselmo, Michael E.; Potts, Geoffrey F.; Shenton, Martha E.; McCarley, Robert W.

In: Archives of General Psychiatry, Vol. 56, No. 11, 11.1999, p. 1001-1005.

Research output: Contribution to journalArticle

Kwon, JS, O'Donnell, BF, Wallenstein, GV, Greene, RW, Hirayasu, Y, Nestor, PG, Hasselmo, ME, Potts, GF, Shenton, ME & McCarley, RW 1999, 'Gamma frequency-range abnormalities to auditory stimulation in schizophrenia', Archives of General Psychiatry, vol. 56, no. 11, pp. 1001-1005. https://doi.org/10.1001/archpsyc.56.11.1001
Kwon, Jun Soo ; O'Donnell, Brian F. ; Wallenstein, Gene V. ; Greene, Robert W. ; Hirayasu, Yoshio ; Nestor, Paul G. ; Hasselmo, Michael E. ; Potts, Geoffrey F. ; Shenton, Martha E. ; McCarley, Robert W. / Gamma frequency-range abnormalities to auditory stimulation in schizophrenia. In: Archives of General Psychiatry. 1999 ; Vol. 56, No. 11. pp. 1001-1005.
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