Gamma glutamyl transpeptidase in normal pregnancy

F. B. Walker, D. L. Hoblit, F. G. Cunningham, B. Combes

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Serum activity of gamma glutamyl transpeptidase (GGT) was measured throughout normal gestation. The GGT values during pregnancy, labor, and the early postpartum period remained within the range found in normal nonpregnant women, and GGT activity was demonstrated in normal placenta. Cord blood had much higher GGT activity than maternal blood. Serum GGT activity is known to increase like that of alkaline phosphatase (ALP) and leucine amino peptidase (LAP) in patients with various liver diseases. Increased serum activity of ALP and LAP in normal pregnancy compromises the diagnostic usefulness of these enzymes in the gravid state. By contrast, the observation that serum GGT does not change in pregnancy suggests that it may be of value in the evaluation of intrapartum hepatic and biliary tract disease.

Original languageEnglish (US)
Pages (from-to)745-749
Number of pages5
JournalObstetrics and Gynecology
Volume43
Issue number5
StatePublished - 1974

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gamma-Glutamyltransferase
Pregnancy
Serum
Leucine
Alkaline Phosphatase
Peptide Hydrolases
Biliary Tract Diseases
Fetal Blood
Postpartum Period
Placenta
Liver Diseases
Mothers
Liver
Enzymes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Walker, F. B., Hoblit, D. L., Cunningham, F. G., & Combes, B. (1974). Gamma glutamyl transpeptidase in normal pregnancy. Obstetrics and Gynecology, 43(5), 745-749.

Gamma glutamyl transpeptidase in normal pregnancy. / Walker, F. B.; Hoblit, D. L.; Cunningham, F. G.; Combes, B.

In: Obstetrics and Gynecology, Vol. 43, No. 5, 1974, p. 745-749.

Research output: Contribution to journalArticle

Walker, FB, Hoblit, DL, Cunningham, FG & Combes, B 1974, 'Gamma glutamyl transpeptidase in normal pregnancy', Obstetrics and Gynecology, vol. 43, no. 5, pp. 745-749.
Walker, F. B. ; Hoblit, D. L. ; Cunningham, F. G. ; Combes, B. / Gamma glutamyl transpeptidase in normal pregnancy. In: Obstetrics and Gynecology. 1974 ; Vol. 43, No. 5. pp. 745-749.
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