Gamma knife stereotactic radiosurgery for low-grade astrocytomas

Mark A. Henderson, Achilles J. Fakiris, Robert D. Timmerman, Robert M. Worth, Simon S. Lo, Thomas C. Witt

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Patients with low-grade astrocytoma (LGA; 8 pilocytic astrocytomas, 2 subependymal giant cell astrocytomas, 2 fibrillary astrocytomas) were selected for treatment with gamma knife stereotactic radiosurgery (GKSRS) based on having a demarcated appearance on CT or MRI and the possibility of dose sparing of adjacent eloquent structures. A median dose of 13 Gy was prescribed to the 50% isodose line, which covered the gross tumor. The median patient age was 17.4 years. The median target volume was 4.4 cm3. With a median follow-up of 48.2 months, 4-year tumor control and overall survival were 77 and 83%, respectively. Only 2 patients experienced symptomatic treatment-related toxicity. GKSRS can provide local control in cases of unresectable or recurrent LGA with a low incidence of side effects in carefully selected patients.

Original languageEnglish (US)
Pages (from-to)161-167
Number of pages7
JournalStereotactic and Functional Neurosurgery
Volume87
Issue number3
DOIs
StatePublished - Jun 1 2009

Keywords

  • Astrocytoma, low grade
  • Gamma knife
  • Glioma
  • Radiosurgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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