Garrotes, springs, ratchets, and whips: putting dynamin models to the test.

S. Sever, H. Damke, S. L. Schmid

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

The GTPase dynamin is essential for clathrin-mediated endocytosis. Numerous new and exciting discoveries regarding dynamin function in vivo and in vitro have led to various models in which dynamin functions directly in membrane fission and the release of clathrin-coated vesicles from the plasma membrane. This would make dynamin unique among GTPases in its ability to act as a mechanochemical enzyme. Here we review the various models and their supporting data. We then discuss new findings that raise doubts as to whether dynamin breaks the paradigm that governs regulatory GTPases.

Original languageEnglish (US)
Pages (from-to)385-392
Number of pages8
JournalTraffic (Copenhagen, Denmark)
Volume1
Issue number5
StatePublished - May 2000

Fingerprint

Dynamins
GTP Phosphohydrolases
Clathrin
Clathrin-Coated Vesicles
Cell membranes
Endocytosis
Cell Membrane
Membranes
Enzymes

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Structural Biology
  • Molecular Biology
  • Genetics

Cite this

Garrotes, springs, ratchets, and whips : putting dynamin models to the test. / Sever, S.; Damke, H.; Schmid, S. L.

In: Traffic (Copenhagen, Denmark), Vol. 1, No. 5, 05.2000, p. 385-392.

Research output: Contribution to journalArticle

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