Gas exchange and lung mechanics during exercise in immature canines raised to maturity after right pneumonectomy

S. Takcda, M. Ramanathan, E. Y. Wu, C. C W Hsia

Research output: Contribution to journalArticle

Abstract

Immature male foxhounds underwent either right pneumonectotny (R-PNX, a=5) or right thoracotomy without pneumonectomy (SHAM, n=6) at 2 months of age. At 1 year after surgery, diffusing capacity of the lung for carbon monoxide (DL) and cardiac output (Qc) during exercise were measured by a rebreathing technique at increasing treadmill loads up to maximal Q2 uptake. Simultaneously total power on the lung (TLW) and dynamic compliance (Cdyn) were measured. Slope and intercept for the relationship of DL to Qc in (L/min)/kg body weights was compared between groups. R-PNX SHAM DL (mi-nun'l torr] kg- ' ) 2.59 0.419 2.46 0-478 NS Qc(nu-min-Lkrl) 688.1±79.1 711.9±12.8 NS Cdyn (ml'CmH2O-1) 57.3±7.5 119.7±12.5 p<0.001 TLW (kgm-min-1) 26.6±2.2 14,7±1.4 p<0.002 These data suggest that postpneumonectomy lung growth returns gas exchange and cardiac output at exercise to normal, but ventilatory power requirement was increased compared with the SHAM group, suggesting persistent abnormalities in the mechanical properties of the lung and/or airways in immature canines after pneumonectomv.

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - 1996

Fingerprint

Pneumonectomy
Mechanics
mechanics
gas exchange
Canidae
exercise
Gases
immatures
lungs
Exercise
Cardiac Output
Lung
dogs
cardiac output
Lung Volume Measurements
Exercise equipment
Thoracotomy
Carbon Monoxide
power requirement
Surgery

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Gas exchange and lung mechanics during exercise in immature canines raised to maturity after right pneumonectomy. / Takcda, S.; Ramanathan, M.; Wu, E. Y.; Hsia, C. C W.

In: FASEB Journal, Vol. 10, No. 3, 1996.

Research output: Contribution to journalArticle

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