Gastric and small bowel ileus after severe burn in rats: The effect of cyclooxygenase-2 inhibitors

Hermes M. Oliveira, Hanaa S. Sallam, Jonathan Espana-Tenorio, David Chinkes, Dai H. Chung, Jiande D.Z. Chen, David N. Herndon

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Gastrointestinal (GI) ileus is a common complication after severe burns. Selective cyclooxygenase-2 inhibitors (COX-2i) improved post-operative ileus, but its effect on burn-induced GI dysmotility is unknown. Our aim was to test whether a COX-2i improves gastric emptying (GE) and small bowel transit (SBT) after burn. Experiment on GE: rats were anesthetized and randomized into sham/scald burn, treated/untreated with COX-2i. Six hours after burn, rats received a phenol red meal and were sacrificed 30 min later. Gastric emptying was determined based on the percentage of phenol red recovered in harvested stomachs. Experiment on SBT: rats received a duodenostomy and were scald/sham burned 5 days later. Six hours after burn, rats received a phenol red meal through the duodenostomy catheter and were sacrificed 100 min later. Geometric center (GC) was calculated for SBT. GE was decreased significantly in burned vs. sham animals (p < 0.001). SBT was significantly impaired in burned vs. sham animals (p < 0.001). The COX-2i improved GE in the burn rats but not GE in the control rats or SBT in the burn rats. COX-2i improves burn-induced delayed GE, suggesting the mediation of the latter via the prostaglandin pathway.

Original languageEnglish (US)
Pages (from-to)1180-1184
Number of pages5
JournalBurns
Volume35
Issue number8
DOIs
StatePublished - Dec 1 2009
Externally publishedYes

Keywords

  • Burn
  • COX-2 inhibitors
  • Gastric emptying
  • Small bowel ileus

ASJC Scopus subject areas

  • Surgery
  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

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  • Cite this

    Oliveira, H. M., Sallam, H. S., Espana-Tenorio, J., Chinkes, D., Chung, D. H., Chen, J. D. Z., & Herndon, D. N. (2009). Gastric and small bowel ileus after severe burn in rats: The effect of cyclooxygenase-2 inhibitors. Burns, 35(8), 1180-1184. https://doi.org/10.1016/j.burns.2009.02.022