Gastric cancer: Recent molecular classification advances, racial disparity, and management implications

Aravind Sanjeevaiah, Naga Cheedella, Caitlin Hester, Matthew R. Porembka

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Gastric adenocarcinoma remains an aggressive and poorly understood malignancy with a heterogeneous presentation and tumor biology. The current histologic and anatomic classification has been ineffective in guiding therapy, with only marginal improvement in outcome over time. Furthermore, the variation in presentation and disease among racial and ethnic groups amplifies the complexity of this cancer. An understanding of the clinical and molecular variability is important for effective treatment. Recent advances in molecular biology have better defined gastric cancer subtypes. We systematically review recent literature on the molecular classification of gastric adenocarcinoma and the associated management implications, with an emphasis on Hispanic and Native American populations.

Original languageEnglish (US)
Pages (from-to)217-224
Number of pages8
JournalJournal of Oncology Practice
Volume14
Issue number4
DOIs
StatePublished - Apr 1 2018

ASJC Scopus subject areas

  • Oncology
  • Oncology(nursing)
  • Health Policy

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