Gastric HCO3- secretion: Relationship with Na+ secretion and effect of acetazolamide in humans

M. Feldman, M. Goldschmiedt

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


We examined the relationship between gastric HCO3- and Na+ secretion under fasting and sham-fed conditions in nine healthy men and also evaluated the effect of the carbonic anhydrase inhibitor acetazolamide on gastric secretion of HCO3- and Na+. Secretion of H+, K+, and Cl- were also measured. Gastric HCO3- secretion rates under fasting and sham-fed conditions closely paralleled Na+ secretion rates. A maximally tolerated intravenous dose (10 mg/kg) of acetazolamide significantly inhibited H+, Cl- and K+ secretion but did not significantly affect Na+ or HCO3- secretion. Thus, the gastric mucosa secretes HCO3- and Na+ in parallel in humans both under fasting and sham-fed conditions. Relative to parietal secretion of HCl, nonparietal secretion of HCO3- and Na+ is resistant to carbonic anhydrase inhibition.

Original languageEnglish (US)
Pages (from-to)G320-G326
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Issue number2 24-2
StatePublished - 1991
Externally publishedYes


  • Acid
  • Bicarbonate
  • Chloride
  • Potassium
  • Sham feeding
  • Sodium

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)


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