Gastric mucosa

Long-term outcome after cure of Helicobacter pylori infection

Francesco Franceschi, Robert M. Genta, Antonio R. Sepulveda

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The histopathological changes due to chronic Helicobacter pylori infection are well characterized. Nevertheless, the clinical and pathological outcomes resulting from the cure of this infection remain incompletely described. In particular, the influence of eradication of H. pylori on nonulcer dyspepsia, the long-term effects of H. pylori eradication of gastric atrophy and intestinal metaplasia, and the role of H. pylori eradication in the prevention of gastric cancer are still unclear. We reviewed 38 studies reported between 1993 and 1999 on the outcome of various disorders related to H. pylori infection after successful eradication. There is general agreement concerning the regression of chronic gastritis, lymphoid follicles, and limited-stage lowi-grade MALT lymphomas of the gastric mucosa after eradication of H. pylori infection. Conversely, there are still major questions on whether H. pylori eradication improves the outcome of premalignant lesions, such as atrophy, intestinal metaplasia, and dysplasia. Finally, some extragastric idiopathic diseases seem to improve in consequence of the eradication of the infection, although there are still no definitive data to support this.

Original languageEnglish (US)
Pages (from-to)17-23
Number of pages7
JournalJournal of Gastroenterology
Volume37
Issue numberSUPPL. 13
DOIs
StatePublished - 2002

Fingerprint

Helicobacter Infections
Gastric Mucosa
Helicobacter pylori
Metaplasia
Atrophy
Marginal Zone B-Cell Lymphoma
Dyspepsia
Gastritis
Infection
Stomach Neoplasms
Stomach

Keywords

  • Extragastric diseases
  • Helicobacter pylori eradication
  • Premalignations

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Gastric mucosa : Long-term outcome after cure of Helicobacter pylori infection. / Franceschi, Francesco; Genta, Robert M.; Sepulveda, Antonio R.

In: Journal of Gastroenterology, Vol. 37, No. SUPPL. 13, 2002, p. 17-23.

Research output: Contribution to journalArticle

Franceschi, Francesco ; Genta, Robert M. ; Sepulveda, Antonio R. / Gastric mucosa : Long-term outcome after cure of Helicobacter pylori infection. In: Journal of Gastroenterology. 2002 ; Vol. 37, No. SUPPL. 13. pp. 17-23.
@article{3452e22621764af5b5b32ef0cc314ad3,
title = "Gastric mucosa: Long-term outcome after cure of Helicobacter pylori infection",
abstract = "The histopathological changes due to chronic Helicobacter pylori infection are well characterized. Nevertheless, the clinical and pathological outcomes resulting from the cure of this infection remain incompletely described. In particular, the influence of eradication of H. pylori on nonulcer dyspepsia, the long-term effects of H. pylori eradication of gastric atrophy and intestinal metaplasia, and the role of H. pylori eradication in the prevention of gastric cancer are still unclear. We reviewed 38 studies reported between 1993 and 1999 on the outcome of various disorders related to H. pylori infection after successful eradication. There is general agreement concerning the regression of chronic gastritis, lymphoid follicles, and limited-stage lowi-grade MALT lymphomas of the gastric mucosa after eradication of H. pylori infection. Conversely, there are still major questions on whether H. pylori eradication improves the outcome of premalignant lesions, such as atrophy, intestinal metaplasia, and dysplasia. Finally, some extragastric idiopathic diseases seem to improve in consequence of the eradication of the infection, although there are still no definitive data to support this.",
keywords = "Extragastric diseases, Helicobacter pylori eradication, Premalignations",
author = "Francesco Franceschi and Genta, {Robert M.} and Sepulveda, {Antonio R.}",
year = "2002",
doi = "10.1007/s535-002-8127-8",
language = "English (US)",
volume = "37",
pages = "17--23",
journal = "Journal of Gastroenterology",
issn = "0944-1174",
publisher = "Springer Japan",
number = "SUPPL. 13",

}

TY - JOUR

T1 - Gastric mucosa

T2 - Long-term outcome after cure of Helicobacter pylori infection

AU - Franceschi, Francesco

AU - Genta, Robert M.

AU - Sepulveda, Antonio R.

PY - 2002

Y1 - 2002

N2 - The histopathological changes due to chronic Helicobacter pylori infection are well characterized. Nevertheless, the clinical and pathological outcomes resulting from the cure of this infection remain incompletely described. In particular, the influence of eradication of H. pylori on nonulcer dyspepsia, the long-term effects of H. pylori eradication of gastric atrophy and intestinal metaplasia, and the role of H. pylori eradication in the prevention of gastric cancer are still unclear. We reviewed 38 studies reported between 1993 and 1999 on the outcome of various disorders related to H. pylori infection after successful eradication. There is general agreement concerning the regression of chronic gastritis, lymphoid follicles, and limited-stage lowi-grade MALT lymphomas of the gastric mucosa after eradication of H. pylori infection. Conversely, there are still major questions on whether H. pylori eradication improves the outcome of premalignant lesions, such as atrophy, intestinal metaplasia, and dysplasia. Finally, some extragastric idiopathic diseases seem to improve in consequence of the eradication of the infection, although there are still no definitive data to support this.

AB - The histopathological changes due to chronic Helicobacter pylori infection are well characterized. Nevertheless, the clinical and pathological outcomes resulting from the cure of this infection remain incompletely described. In particular, the influence of eradication of H. pylori on nonulcer dyspepsia, the long-term effects of H. pylori eradication of gastric atrophy and intestinal metaplasia, and the role of H. pylori eradication in the prevention of gastric cancer are still unclear. We reviewed 38 studies reported between 1993 and 1999 on the outcome of various disorders related to H. pylori infection after successful eradication. There is general agreement concerning the regression of chronic gastritis, lymphoid follicles, and limited-stage lowi-grade MALT lymphomas of the gastric mucosa after eradication of H. pylori infection. Conversely, there are still major questions on whether H. pylori eradication improves the outcome of premalignant lesions, such as atrophy, intestinal metaplasia, and dysplasia. Finally, some extragastric idiopathic diseases seem to improve in consequence of the eradication of the infection, although there are still no definitive data to support this.

KW - Extragastric diseases

KW - Helicobacter pylori eradication

KW - Premalignations

UR - http://www.scopus.com/inward/record.url?scp=0036328250&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036328250&partnerID=8YFLogxK

U2 - 10.1007/s535-002-8127-8

DO - 10.1007/s535-002-8127-8

M3 - Article

VL - 37

SP - 17

EP - 23

JO - Journal of Gastroenterology

JF - Journal of Gastroenterology

SN - 0944-1174

IS - SUPPL. 13

ER -