Gastric ulcer recurrence: Foliow-up of a double-blind, placebo-controlled trial

J. D. Wolosin, S. L. Gertler, W. L. Peterson, M. A. Sandersfeld, J. I. Isenberg

Research output: Contribution to journalArticle

5 Scopus citations


Following a multicenter, double-blind trial comparing ci-metidine, antacid, and placebo for the treatment of gastric ulcer, patients whose ulcers had healed were followed prospectively to assess the frequency of ulcer relapse. Fifty-eight patients entered the follow-up study. Patients were encouraged to discontinue smoking and excessive ethanol intake, but were not maintained on antiulcer medications. Clinical evaluation was performed at monthly intervals; repeat en-doscopy was performed at the time of symptom recurrence or at 6 to 9 months after ulcer healing. Gastric ulcer recurred in 20 of 58 patients (35%). While 15 (75%) with ulcer recurrence had symptoms, 5 (25%) had asymptomatic recurrences. There were no differences in the incidence of ulcer relapse or symptom recurrences between groups. We conclude that gastric ulcers recur in approximately one-third of patients within 9 months of ulcer healing.

Original languageEnglish (US)
Pages (from-to)12-16
Number of pages5
JournalJournal of Clinical Gastroenterology
Issue number1
StatePublished - Feb 1989


  • Antacids
  • Cimetidine
  • Clinical trials
  • Gastric ulcer
  • Placebo

ASJC Scopus subject areas

  • Gastroenterology

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    Wolosin, J. D., Gertler, S. L., Peterson, W. L., Sandersfeld, M. A., & Isenberg, J. I. (1989). Gastric ulcer recurrence: Foliow-up of a double-blind, placebo-controlled trial. Journal of Clinical Gastroenterology, 11(1), 12-16.