Gastric ulcer recurrence

Follow-up of a double-blind, placebo-controlled trial

J. D. Wolosin, S. L. Gertler, W. L. Peterson, M. A. Sandersfeld, J. I. Isenberg

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Following a multicenter, double-blind trial comparing cimetidine, antacid, and placebo for the treatment of gastric ulcer, patients whose ulcers had healed were followed prospectively to assess the frequency of ulcer relapse. Fifty-eight patients entered the follow-up study. Patients were encouraged to discontinue smoking and excessive ethanol intake, but were not maintained on antiulcer medications. Clinical evaluation was performed at monthly intervals; repeat endoscopy was performed at the time of symptom recurrence or at 6 to 9 months after ulcer healing. Gastric ulcer recurred in 20 of 58 patients (35%). While 15 (75%) with ulcer recurrence had symptoms, 5 (25%) had asymptomatic recurrences. There were no differences in the incidence of ulcer relapse or symptom recurrences between groups. We conclude that gastric ulcers recur in approximately one-third of patients within 9 months of ulcer healing.

Original languageEnglish (US)
Pages (from-to)12-16
Number of pages5
JournalJournal of Clinical Gastroenterology
Volume11
Issue number1
StatePublished - 1989

Fingerprint

Stomach Ulcer
Ulcer
Placebos
Recurrence
Antacids
Cimetidine
Endoscopy
Ethanol
Smoking
Incidence

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Wolosin, J. D., Gertler, S. L., Peterson, W. L., Sandersfeld, M. A., & Isenberg, J. I. (1989). Gastric ulcer recurrence: Follow-up of a double-blind, placebo-controlled trial. Journal of Clinical Gastroenterology, 11(1), 12-16.

Gastric ulcer recurrence : Follow-up of a double-blind, placebo-controlled trial. / Wolosin, J. D.; Gertler, S. L.; Peterson, W. L.; Sandersfeld, M. A.; Isenberg, J. I.

In: Journal of Clinical Gastroenterology, Vol. 11, No. 1, 1989, p. 12-16.

Research output: Contribution to journalArticle

Wolosin, JD, Gertler, SL, Peterson, WL, Sandersfeld, MA & Isenberg, JI 1989, 'Gastric ulcer recurrence: Follow-up of a double-blind, placebo-controlled trial', Journal of Clinical Gastroenterology, vol. 11, no. 1, pp. 12-16.
Wolosin JD, Gertler SL, Peterson WL, Sandersfeld MA, Isenberg JI. Gastric ulcer recurrence: Follow-up of a double-blind, placebo-controlled trial. Journal of Clinical Gastroenterology. 1989;11(1):12-16.
Wolosin, J. D. ; Gertler, S. L. ; Peterson, W. L. ; Sandersfeld, M. A. ; Isenberg, J. I. / Gastric ulcer recurrence : Follow-up of a double-blind, placebo-controlled trial. In: Journal of Clinical Gastroenterology. 1989 ; Vol. 11, No. 1. pp. 12-16.
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