Gastritis

Richard H. Lash, Robert M. Genta

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Gastritis is a broad term that includes a wide variety of non-neoplastic conditions of the gastric mucosa. The most widely used classification is the Updated Sydney System, which separates gastritis (characterized by inflammation) and gastropathy (mucosal aberrations with little or no inflammation). The most common cause of gastritis is H. pylori infection, which may cause antral-predominant non-atrophic inflammation (a risk factor for peptic ulcer) or atrophic pangastritis (a risk factor for gastric adenocarcinoma). Gastritides of unknown etiology include autoimmune gastritis (which leads to pernicious anemia), lymphocytic, and granulomatous gastritis. Amongst populations living in industrialized parts of the world the most prevalent gastric abnormality is reactive gastropathy. This is a histopathologic condition associated with chemical injury (most often caused by NSAIDs) characterized by epithelial regeneration, foveolar hyperplasia, and smooth muscle proliferation. Vascular abnormalities in the gastric mucosa and wall may cause hemorrhagic gastropathies, of which gastric antral vascular ectasia (GAVE), often associated with autoimmune disorders, is the best characterized. Hypertrophy of the oxyntic mucosa defines the hypertrophic gastropathies: Ménétrier's disease, a condition of unknown origin manifested by severe protein loss, and the Zollinger-Ellison syndrome, usually caused by a gastrin-secreting neuroendocrine tumor, which is associated with multiple recurrent refractory peptic ulcers.

Original languageEnglish (US)
Title of host publicationTextbook of Clinical Gastroenterology and Hepatology: Second Edition
PublisherWiley-Blackwell
Pages234-247
Number of pages14
ISBN (Print)1405191821, 9781405191821
DOIs
StatePublished - Apr 16 2012

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Gastritis
Gastric Mucosa
Inflammation
Peptic Ulcer
Stomach
Gastric Antral Vascular Ectasia
Zollinger-Ellison Syndrome
Pernicious Anemia
Neuroendocrine Tumors
Pylorus
Gastrins
Non-Steroidal Anti-Inflammatory Agents
Hypertrophy
Hyperplasia
Smooth Muscle
Blood Vessels
Regeneration
Mucous Membrane
Adenocarcinoma
Wounds and Injuries

Keywords

  • Atrophic gastritis
  • Autoimmune gastritis
  • Gastritis
  • Granulomatous gastritis
  • Helicobacter pylori
  • Hypertrophic gastropathy
  • MALT lymphoma
  • Ménétrier's disease
  • Stomach
  • Zollinger-Ellison syndrome

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lash, R. H., & Genta, R. M. (2012). Gastritis. In Textbook of Clinical Gastroenterology and Hepatology: Second Edition (pp. 234-247). Wiley-Blackwell. https://doi.org/10.1002/9781118321386.ch33

Gastritis. / Lash, Richard H.; Genta, Robert M.

Textbook of Clinical Gastroenterology and Hepatology: Second Edition. Wiley-Blackwell, 2012. p. 234-247.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lash, RH & Genta, RM 2012, Gastritis. in Textbook of Clinical Gastroenterology and Hepatology: Second Edition. Wiley-Blackwell, pp. 234-247. https://doi.org/10.1002/9781118321386.ch33
Lash RH, Genta RM. Gastritis. In Textbook of Clinical Gastroenterology and Hepatology: Second Edition. Wiley-Blackwell. 2012. p. 234-247 https://doi.org/10.1002/9781118321386.ch33
Lash, Richard H. ; Genta, Robert M. / Gastritis. Textbook of Clinical Gastroenterology and Hepatology: Second Edition. Wiley-Blackwell, 2012. pp. 234-247
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