Gastroesophageal reflux disease

Kalani Olmsted, Deborah B. Diercks

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Opioids such as morphine are often used early in patients subsequently diagnosed with gastroesophageal reflux disease (GERD). Antacids provide GERD relief by buffering the refluxed gastric contents. Antacids are readily available, relatively safe, and fast acting. Antacids constitute first-line GERD therapy in pregnancy. Proton pump inhibitors (PPIs) are a first-line treatment for non-cardiac chest pain, and for GERD in particular. H2-receptor antagonists such as ranitidine (150 mg PO as needed for GERD pain) have been shown in double-blinded trials to achieve better on-demand pain relief than antacids. Prokinetic drugs such as metoclopramide and cisapride are postulated to relieve GERD by increasing resting lower esophageal sphincter tone and increasing gastric emptying. The novel prokinetic agent itopride has promising preliminary results in an open-label GERD trial, but recommendation for its acute care use must await further data.

Original languageEnglish (US)
Title of host publicationEmergency Department Analgesia: An Evidence-Based Guide
PublisherCambridge University Press
Pages225-231
Number of pages7
ISBN (Print)9780511544835, 9780521696012
DOIs
StatePublished - Jan 1 2008

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Gastroesophageal Reflux
Antacids
Cisapride
Pain
Lower Esophageal Sphincter
Histamine H2 Receptors
Gastrointestinal Contents
Metoclopramide
Ranitidine
Proton Pump Inhibitors
Gastric Emptying
Chest Pain
Morphine
Opioid Analgesics
Pregnancy
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Olmsted, K., & Diercks, D. B. (2008). Gastroesophageal reflux disease. In Emergency Department Analgesia: An Evidence-Based Guide (pp. 225-231). Cambridge University Press. https://doi.org/10.1017/CBO9780511544835.033

Gastroesophageal reflux disease. / Olmsted, Kalani; Diercks, Deborah B.

Emergency Department Analgesia: An Evidence-Based Guide. Cambridge University Press, 2008. p. 225-231.

Research output: Chapter in Book/Report/Conference proceedingChapter

Olmsted, K & Diercks, DB 2008, Gastroesophageal reflux disease. in Emergency Department Analgesia: An Evidence-Based Guide. Cambridge University Press, pp. 225-231. https://doi.org/10.1017/CBO9780511544835.033
Olmsted K, Diercks DB. Gastroesophageal reflux disease. In Emergency Department Analgesia: An Evidence-Based Guide. Cambridge University Press. 2008. p. 225-231 https://doi.org/10.1017/CBO9780511544835.033
Olmsted, Kalani ; Diercks, Deborah B. / Gastroesophageal reflux disease. Emergency Department Analgesia: An Evidence-Based Guide. Cambridge University Press, 2008. pp. 225-231
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