Gastrointestinal chronic graft-versus-host disease: Management options

Farrukh Awan, Mehdi Hamadani

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Chronic graft-versus-host disease (GVHD) is a common and debilitating condition afflicting a number of allogeneic stem cell recipients more than 100 days after their transplant. Limited options are available for the acute management of patients with severe gastrointestinal (GI) symptoms including gastric bleeding. Along with increased immunosuppression and aggressive supportive care, we report here the use of aminocaproic acid in the management of patients with GI bleeding resulting from severe GVHD. The use of aminocaproic acid enabled us to reduce the frequency and number of blood product transfusions required to manage our patient. Anti-fibrinolytic agents may therefore serve as useful adjunctive but underutilized therapy in the management of patients with severe GI chronic GVHD.

Original languageEnglish (US)
Pages (from-to)49-51
Number of pages3
JournalJournal of Oncology Pharmacy Practice
Volume13
Issue number1
DOIs
StatePublished - Jun 15 2007
Externally publishedYes

Keywords

  • Aminocaproic acid
  • Anti-fibrinolytics
  • Gastrointestinal bleeding
  • Graft-versus-host disease

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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