Gastrointestinal defect closure using a novel through-the-scope helix tack and suture device compared to endoscopic clips in a survival porcine model (with video)

Ariosto Hernandez, Neil B. Marya, Tarek Sawas, Elizabeth Rajan, Naomi M. Gades, Louis M. Wong Kee Song, Barham K. Abu Dayyeh, Navtej Buttar, Andrew C. Storm

Research output: Contribution to journalArticlepeer-review

Abstract

Background and aims Endoscopic resections are associated with bleeding and perforation and may be managed with through-the-scope (TTS) clips, over-the-scope clips and endoscopic suturing. The aim of this preclinical study was to compare technical success of closure using a novel TTS tissue helix tack and suture device (X-Tack) to TTS clips in a porcine model. Materials and methods Four subjects underwent 40 mucosal resections, diameter range 25-50mm, in the stomach (n=24) and colon (n=16). Closures were randomized to X-Tack (n=24) or clip (n=16). Animals underwent weekly endoscopic follow-up for 4 weeks. Results Technical closure with X-Tack was successful in 24 of 24 (100%) cases and with clips in 13 of 16 cases (81.3%) (P =0.0001). One colonic perforation occurred and was successfully managed using X-Tack. The rate of healing was not statistically different between the groups, and all sites healed at 4 weeks including the perforation and were confirmed by histology. Conclusions Compared to TTS clip, X-Tack is superior for effecting large mucosal defect closure, including durable sealing of full-thickness perforation. There was no difference in rate of healing between devices.

Original languageEnglish (US)
Pages (from-to)E572-E577
JournalEndoscopy International Open
Volume9
Issue number4
DOIs
StatePublished - Apr 1 2021
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Gastroenterology

Fingerprint

Dive into the research topics of 'Gastrointestinal defect closure using a novel through-the-scope helix tack and suture device compared to endoscopic clips in a survival porcine model (with video)'. Together they form a unique fingerprint.

Cite this