Gastrointestinal, Pancreatic, and Hepatobiliary Manifestations of Cystic Fibrosis

Meghana Nitin Sathe, Alvin Jay Freeman

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Pulmonary disease is the primary cause of morbidity and mortality in people with cystic fibrosis (CF), but significant involvement within gastrointestinal, pancreatic, and hepatobiliary systems occurs as well. As in the airways, defects in CFTR alter epithelial surface fluid, mucus viscosity, and pH, increasing risk of stasis through the various hollow epithelial-lined structures of the gastrointestinal tract. This exerts secondary influences that are responsible for most gastrointestinal, pancreatic, and hepatobiliary manifestations of CF. Understanding these gastrointestinal morbidities of CF is essential in understanding and treating CF as a multisystem disease process and improving overall patient care.

Original languageEnglish (US)
Pages (from-to)679-698
Number of pages20
JournalPediatric Clinics of North America
Volume63
Issue number4
DOIs
StatePublished - Aug 1 2016

Keywords

  • CF and GI manifestations
  • CF pancreas
  • CFLD (CF liver disease)
  • PERT (pancreatic enzyme replacement therapy)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

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