Gastrointestinal Symptoms Predictors of Health-Related Quality of Life in Patients with Inflammatory Bowel Disease

on behalf of the Pediatric Quality of Life Inventory Gastrointestinal Symptoms Module Testing Study Consortium

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

OBJECTIVES:: To investigate the multidimensional gastrointestinal symptoms predictors of generic health-related quality of life (HRQOL) in pediatric patients with inflammatory bowel disease (IBD) from the perspectives of pediatric patients and parents. METHODS:: The Pediatric Quality of Life Inventory (PedsQL) Gastrointestinal Symptoms Scales and PedsQL 4.0 Generic Core Scales were completed in a 9-site study by 260 families of patients with IBD. Gastrointestinal Symptoms Scales measuring stomach pain, food and drink limits, gas and bloating, constipation, blood in stool, and diarrhea were identified as clinically important symptom differentiators from healthy controls based on prior findings, and subsequently tested for bivariate and multivariate linear associations with overall HRQOL (Generic Core Scales). RESULTS:: Stomach pain, food and drink limits, gas and bloating, constipation, blood in stool, and diarrhea were significantly associated with decreased HRQOL in bivariate analyses (Ps?<?0.001). In predictive models utilizing hierarchical multiple regression analyses controlling for age, gender, and race/ethnicity, gastrointestinal symptoms accounted for an additional 40 percent of the variance in patient self-reported HRQOL (P?<?0.001) and 37 percent of the variance in parent proxy-reported HRQOL (P?<?0.001), reflecting large effect sizes. Stomach pain, food and drink limits, and constipation were significant individual patient-reported predictors after controlling for the other gastrointestinal symptoms in the predictive models. CONCLUSIONS:: Patient-reported gastrointestinal symptoms differentially predicted HRQOL. Identifying the specific gastrointestinal symptoms from a standardized multidimensional gastrointestinal symptoms profile that are the most important predictors from the patient perspective facilitates a patient-centered approach for interventions designed to ameliorate impaired HRQOL.

Original languageEnglish (US)
JournalJournal of Pediatric Gastroenterology and Nutrition
DOIs
StateAccepted/In press - Oct 5 2016

Fingerprint

Inflammatory Bowel Diseases
Quality of Life
Constipation
Stomach
Pediatrics
Pain
Food
Diarrhea
Gases
Proxy
Parents
Regression Analysis
Equipment and Supplies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

Cite this

Gastrointestinal Symptoms Predictors of Health-Related Quality of Life in Patients with Inflammatory Bowel Disease. / on behalf of the Pediatric Quality of Life Inventory Gastrointestinal Symptoms Module Testing Study Consortium.

In: Journal of Pediatric Gastroenterology and Nutrition, 05.10.2016.

Research output: Contribution to journalArticle

on behalf of the Pediatric Quality of Life Inventory Gastrointestinal Symptoms Module Testing Study Consortium. / Gastrointestinal Symptoms Predictors of Health-Related Quality of Life in Patients with Inflammatory Bowel Disease. In: Journal of Pediatric Gastroenterology and Nutrition. 2016.
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title = "Gastrointestinal Symptoms Predictors of Health-Related Quality of Life in Patients with Inflammatory Bowel Disease",
abstract = "OBJECTIVES:: To investigate the multidimensional gastrointestinal symptoms predictors of generic health-related quality of life (HRQOL) in pediatric patients with inflammatory bowel disease (IBD) from the perspectives of pediatric patients and parents. METHODS:: The Pediatric Quality of Life Inventory (PedsQL) Gastrointestinal Symptoms Scales and PedsQL 4.0 Generic Core Scales were completed in a 9-site study by 260 families of patients with IBD. Gastrointestinal Symptoms Scales measuring stomach pain, food and drink limits, gas and bloating, constipation, blood in stool, and diarrhea were identified as clinically important symptom differentiators from healthy controls based on prior findings, and subsequently tested for bivariate and multivariate linear associations with overall HRQOL (Generic Core Scales). RESULTS:: Stomach pain, food and drink limits, gas and bloating, constipation, blood in stool, and diarrhea were significantly associated with decreased HRQOL in bivariate analyses (Ps?<?0.001). In predictive models utilizing hierarchical multiple regression analyses controlling for age, gender, and race/ethnicity, gastrointestinal symptoms accounted for an additional 40 percent of the variance in patient self-reported HRQOL (P?<?0.001) and 37 percent of the variance in parent proxy-reported HRQOL (P?<?0.001), reflecting large effect sizes. Stomach pain, food and drink limits, and constipation were significant individual patient-reported predictors after controlling for the other gastrointestinal symptoms in the predictive models. CONCLUSIONS:: Patient-reported gastrointestinal symptoms differentially predicted HRQOL. Identifying the specific gastrointestinal symptoms from a standardized multidimensional gastrointestinal symptoms profile that are the most important predictors from the patient perspective facilitates a patient-centered approach for interventions designed to ameliorate impaired HRQOL.",
author = "{on behalf of the Pediatric Quality of Life Inventory Gastrointestinal Symptoms Module Testing Study Consortium} and Varni, {James W.} and Shulman, {Robert J.} and Self, {Mariella M.} and Saeed, {Shehzad A.} and Patel, {Ashish S.} and Samuel Nurko and Neigut, {Deborah A.} and Miguel Saps and Franciosi, {James P.} and Denham, {Jolanda M.} and Zacur, {George M.} and Dark, {Chelsea Vaughan} and Bendo, {Cristiane B.} and Pohl, {John F.}",
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AU - on behalf of the Pediatric Quality of Life Inventory Gastrointestinal Symptoms Module Testing Study Consortium

AU - Varni, James W.

AU - Shulman, Robert J.

AU - Self, Mariella M.

AU - Saeed, Shehzad A.

AU - Patel, Ashish S.

AU - Nurko, Samuel

AU - Neigut, Deborah A.

AU - Saps, Miguel

AU - Franciosi, James P.

AU - Denham, Jolanda M.

AU - Zacur, George M.

AU - Dark, Chelsea Vaughan

AU - Bendo, Cristiane B.

AU - Pohl, John F.

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N2 - OBJECTIVES:: To investigate the multidimensional gastrointestinal symptoms predictors of generic health-related quality of life (HRQOL) in pediatric patients with inflammatory bowel disease (IBD) from the perspectives of pediatric patients and parents. METHODS:: The Pediatric Quality of Life Inventory (PedsQL) Gastrointestinal Symptoms Scales and PedsQL 4.0 Generic Core Scales were completed in a 9-site study by 260 families of patients with IBD. Gastrointestinal Symptoms Scales measuring stomach pain, food and drink limits, gas and bloating, constipation, blood in stool, and diarrhea were identified as clinically important symptom differentiators from healthy controls based on prior findings, and subsequently tested for bivariate and multivariate linear associations with overall HRQOL (Generic Core Scales). RESULTS:: Stomach pain, food and drink limits, gas and bloating, constipation, blood in stool, and diarrhea were significantly associated with decreased HRQOL in bivariate analyses (Ps?<?0.001). In predictive models utilizing hierarchical multiple regression analyses controlling for age, gender, and race/ethnicity, gastrointestinal symptoms accounted for an additional 40 percent of the variance in patient self-reported HRQOL (P?<?0.001) and 37 percent of the variance in parent proxy-reported HRQOL (P?<?0.001), reflecting large effect sizes. Stomach pain, food and drink limits, and constipation were significant individual patient-reported predictors after controlling for the other gastrointestinal symptoms in the predictive models. CONCLUSIONS:: Patient-reported gastrointestinal symptoms differentially predicted HRQOL. Identifying the specific gastrointestinal symptoms from a standardized multidimensional gastrointestinal symptoms profile that are the most important predictors from the patient perspective facilitates a patient-centered approach for interventions designed to ameliorate impaired HRQOL.

AB - OBJECTIVES:: To investigate the multidimensional gastrointestinal symptoms predictors of generic health-related quality of life (HRQOL) in pediatric patients with inflammatory bowel disease (IBD) from the perspectives of pediatric patients and parents. METHODS:: The Pediatric Quality of Life Inventory (PedsQL) Gastrointestinal Symptoms Scales and PedsQL 4.0 Generic Core Scales were completed in a 9-site study by 260 families of patients with IBD. Gastrointestinal Symptoms Scales measuring stomach pain, food and drink limits, gas and bloating, constipation, blood in stool, and diarrhea were identified as clinically important symptom differentiators from healthy controls based on prior findings, and subsequently tested for bivariate and multivariate linear associations with overall HRQOL (Generic Core Scales). RESULTS:: Stomach pain, food and drink limits, gas and bloating, constipation, blood in stool, and diarrhea were significantly associated with decreased HRQOL in bivariate analyses (Ps?<?0.001). In predictive models utilizing hierarchical multiple regression analyses controlling for age, gender, and race/ethnicity, gastrointestinal symptoms accounted for an additional 40 percent of the variance in patient self-reported HRQOL (P?<?0.001) and 37 percent of the variance in parent proxy-reported HRQOL (P?<?0.001), reflecting large effect sizes. Stomach pain, food and drink limits, and constipation were significant individual patient-reported predictors after controlling for the other gastrointestinal symptoms in the predictive models. CONCLUSIONS:: Patient-reported gastrointestinal symptoms differentially predicted HRQOL. Identifying the specific gastrointestinal symptoms from a standardized multidimensional gastrointestinal symptoms profile that are the most important predictors from the patient perspective facilitates a patient-centered approach for interventions designed to ameliorate impaired HRQOL.

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