Gata2 is a rheostat for mesenchymal stem cell fate in male mice

Xiaoxiao Li, Hoangdinh Huynh, Hao Zuo, Marjo Salminen, Yihong Wan

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Gata2 is a zinc finger transcription factor that is important in hematopoiesis and neuronal development. However, the roles of Gata2 in the mesenchymal lineages are poorly understood. In vitro studies suggest that Gata2 modulates adipocyte differentiation and mesenchymal stem cell (MSC) proliferation. To systematically determine the in vivo functions of Gata2 in the MSC lineage commitment and development, we have generated three mouse models in which Gata2 is specifically deleted in MSCs, adipocytes, or osteoblasts. During the MSC expansion stage, Gata2 promotes proliferation and attenuates differentiation; thereby Gata2 loss in MSCs results in enhanced differentiation of both adipocytes and osteoblasts. During the differentiation stage, Gata2 also plays MSC-independent roles to impede lineage commitment; hence, Gata2 loss in adipocyte or osteoblast lineages also augments adipogenesis and osteoblastogenesis, respectively. These findings reveal Gata2 as a crucial rheostat of MSC fate to control osteoblast and adipocyte lineage development.

Original languageEnglish (US)
Pages (from-to)1021-1028
Number of pages8
JournalEndocrinology
Volume157
Issue number3
DOIs
StatePublished - Mar 2016

ASJC Scopus subject areas

  • Endocrinology

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