Gatekeepers of chromatin

Small metabolites elicit big changes in gene expression

Salma Kaochar, Benjamin P. Tu

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Eukaryotes are constantly fine-tuning their gene expression programs in response to the demands of the environment and the availability of nutrients. Such dynamic regulation of the genome necessitates versatile chromatin architecture. Rapid changes in transcript levels are brought about via a wide range of post-translational modifications of the histone proteins that control chromatin structure. Many enzymes responsible for these modifications have been identified and they require various metabolic cofactors or substrates for their activity. Herein, we highlight recent developments that have begun to reveal particular cellular metabolites that might in fact be underappreciated regulators of gene expression through their ability to modulate particular histone modifications.

Original languageEnglish (US)
Pages (from-to)477-483
Number of pages7
JournalTrends in Biochemical Sciences
Volume37
Issue number11
DOIs
StatePublished - Nov 2012

Fingerprint

Metabolites
Gene expression
Histones
Chromatin
Histone Code
Gene Expression
Post Translational Protein Processing
Regulator Genes
Eukaryota
Nutrients
Tuning
Genes
Availability
Genome
Food
Substrates
Enzymes
Proteins

Keywords

  • Acetyl-CoA
  • Acetylation
  • Epigenetics
  • Histones
  • Methylation
  • S-adenosylmethionine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Gatekeepers of chromatin : Small metabolites elicit big changes in gene expression. / Kaochar, Salma; Tu, Benjamin P.

In: Trends in Biochemical Sciences, Vol. 37, No. 11, 11.2012, p. 477-483.

Research output: Contribution to journalArticle

@article{637ed90b43724dbba9e2424f02d37eef,
title = "Gatekeepers of chromatin: Small metabolites elicit big changes in gene expression",
abstract = "Eukaryotes are constantly fine-tuning their gene expression programs in response to the demands of the environment and the availability of nutrients. Such dynamic regulation of the genome necessitates versatile chromatin architecture. Rapid changes in transcript levels are brought about via a wide range of post-translational modifications of the histone proteins that control chromatin structure. Many enzymes responsible for these modifications have been identified and they require various metabolic cofactors or substrates for their activity. Herein, we highlight recent developments that have begun to reveal particular cellular metabolites that might in fact be underappreciated regulators of gene expression through their ability to modulate particular histone modifications.",
keywords = "Acetyl-CoA, Acetylation, Epigenetics, Histones, Methylation, S-adenosylmethionine",
author = "Salma Kaochar and Tu, {Benjamin P.}",
year = "2012",
month = "11",
doi = "10.1016/j.tibs.2012.07.008",
language = "English (US)",
volume = "37",
pages = "477--483",
journal = "Trends in Biochemical Sciences",
issn = "0376-5067",
publisher = "Elsevier Limited",
number = "11",

}

TY - JOUR

T1 - Gatekeepers of chromatin

T2 - Small metabolites elicit big changes in gene expression

AU - Kaochar, Salma

AU - Tu, Benjamin P.

PY - 2012/11

Y1 - 2012/11

N2 - Eukaryotes are constantly fine-tuning their gene expression programs in response to the demands of the environment and the availability of nutrients. Such dynamic regulation of the genome necessitates versatile chromatin architecture. Rapid changes in transcript levels are brought about via a wide range of post-translational modifications of the histone proteins that control chromatin structure. Many enzymes responsible for these modifications have been identified and they require various metabolic cofactors or substrates for their activity. Herein, we highlight recent developments that have begun to reveal particular cellular metabolites that might in fact be underappreciated regulators of gene expression through their ability to modulate particular histone modifications.

AB - Eukaryotes are constantly fine-tuning their gene expression programs in response to the demands of the environment and the availability of nutrients. Such dynamic regulation of the genome necessitates versatile chromatin architecture. Rapid changes in transcript levels are brought about via a wide range of post-translational modifications of the histone proteins that control chromatin structure. Many enzymes responsible for these modifications have been identified and they require various metabolic cofactors or substrates for their activity. Herein, we highlight recent developments that have begun to reveal particular cellular metabolites that might in fact be underappreciated regulators of gene expression through their ability to modulate particular histone modifications.

KW - Acetyl-CoA

KW - Acetylation

KW - Epigenetics

KW - Histones

KW - Methylation

KW - S-adenosylmethionine

UR - http://www.scopus.com/inward/record.url?scp=84867906972&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867906972&partnerID=8YFLogxK

U2 - 10.1016/j.tibs.2012.07.008

DO - 10.1016/j.tibs.2012.07.008

M3 - Article

VL - 37

SP - 477

EP - 483

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

SN - 0376-5067

IS - 11

ER -