Gazdar Strain of Murine Sarcoma Virus. Biologic and Antigenic Interactions with the Heterologous Hamster Host

P. S. Sarma, A. F. Gazdar, H. C. Turner, P. D. Kunchorn

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The biologic and antigenic interactions of a new strain of mouse sarcoma virus, Gazdar MSV (Gz-MSV), with the heterologous hamster host are described. Hamster tumors as well as cell lines derived from hamster tumors contained noninfectious C-type virus particles. The species-specific gs-1 antigen of the murine leukemia viruses was detected in various hamster tumor and tissue culture preparations including preparations of purified virus. Hamsters bearing primary or transplanted Gz-MSV hamster tumors consistently developed high titers of CF antibodies against the homologous Gz-MSV tumor antigens as well as against purified preparations of mouse leukemia viruses. The gs antisera from such hamsters were found to be as useful as the presently used M-MSV rat sera for the detection of the murine leukemia gs viral antigens and infectious virus by the COMUL test.

Original languageEnglish (US)
Pages (from-to)928-933
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Volume140
Issue number3
DOIs
StatePublished - Jul 1972

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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