The biologic and antigenic interactions of a new strain of mouse sarcoma virus, Gazdar MSV (Gz-MSV), with the heterologous hamster host are described. Hamster tumors as well as cell lines derived from hamster tumors contained noninfectious C-type virus particles. The species-specific gs-1 antigen of the murine leukemia viruses was detected in various hamster tumor and tissue culture preparations including preparations of purified virus. Hamsters bearing primary or transplanted Gz-MSV hamster tumors consistently developed high titers of CF antibodies against the homologous Gz-MSV tumor antigens as well as against purified preparations of mouse leukemia viruses. The gs antisera from such hamsters were found to be as useful as the presently used M-MSV rat sera for the detection of the murine leukemia gs viral antigens and infectious virus by the COMUL test.
|Original language||English (US)|
|Number of pages||6|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Jul 1972|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)