Gazdar Strain of Murine Sarcoma Virus. Biologic and Antigenic Interactions with the Heterologous Hamster Host

P. S. Sarma; A. F. Gazdar; H. C. Turner; P. D. Kunchorn

doi:10.3181/00379727-140-36582

Gazdar Strain of Murine Sarcoma Virus. Biologic and Antigenic Interactions with the Heterologous Hamster Host

P. S. Sarma, A. F. Gazdar, H. C. Turner, P. D. Kunchorn

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Abstract

The biologic and antigenic interactions of a new strain of mouse sarcoma virus, Gazdar MSV (Gz-MSV), with the heterologous hamster host are described. Hamster tumors as well as cell lines derived from hamster tumors contained noninfectious C-type virus particles. The species-specific gs-1 antigen of the murine leukemia viruses was detected in various hamster tumor and tissue culture preparations including preparations of purified virus. Hamsters bearing primary or transplanted Gz-MSV hamster tumors consistently developed high titers of CF antibodies against the homologous Gz-MSV tumor antigens as well as against purified preparations of mouse leukemia viruses. The gs antisera from such hamsters were found to be as useful as the presently used M-MSV rat sera for the detection of the murine leukemia gs viral antigens and infectious virus by the COMUL test.

Original language	English (US)
Pages (from-to)	928-933
Number of pages	6
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	140
Issue number	3
DOIs	https://doi.org/10.3181/00379727-140-36582
State	Published - Jul 1972

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "Gazdar Strain of Murine Sarcoma Virus. Biologic and Antigenic Interactions with the Heterologous Hamster Host",

abstract = "The biologic and antigenic interactions of a new strain of mouse sarcoma virus, Gazdar MSV (Gz-MSV), with the heterologous hamster host are described. Hamster tumors as well as cell lines derived from hamster tumors contained noninfectious C-type virus particles. The species-specific gs-1 antigen of the murine leukemia viruses was detected in various hamster tumor and tissue culture preparations including preparations of purified virus. Hamsters bearing primary or transplanted Gz-MSV hamster tumors consistently developed high titers of CF antibodies against the homologous Gz-MSV tumor antigens as well as against purified preparations of mouse leukemia viruses. The gs antisera from such hamsters were found to be as useful as the presently used M-MSV rat sera for the detection of the murine leukemia gs viral antigens and infectious virus by the COMUL test.",

author = "Sarma, {P. S.} and Gazdar, {A. F.} and Turner, {H. C.} and Kunchorn, {P. D.}",

note = "Funding Information: This work was supported by Contract PH70-2068C of the Special Cancer Virus Program of the National Cancer Institute, Bethesda, MD 20014.",

year = "1972",

month = jul,

doi = "10.3181/00379727-140-36582",

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journal = "Proceedings of the Society for Experimental Biology and Medicine",

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T1 - Gazdar Strain of Murine Sarcoma Virus. Biologic and Antigenic Interactions with the Heterologous Hamster Host

AU - Sarma, P. S.

AU - Gazdar, A. F.

AU - Turner, H. C.

AU - Kunchorn, P. D.

N1 - Funding Information: This work was supported by Contract PH70-2068C of the Special Cancer Virus Program of the National Cancer Institute, Bethesda, MD 20014.

PY - 1972/7

Y1 - 1972/7

N2 - The biologic and antigenic interactions of a new strain of mouse sarcoma virus, Gazdar MSV (Gz-MSV), with the heterologous hamster host are described. Hamster tumors as well as cell lines derived from hamster tumors contained noninfectious C-type virus particles. The species-specific gs-1 antigen of the murine leukemia viruses was detected in various hamster tumor and tissue culture preparations including preparations of purified virus. Hamsters bearing primary or transplanted Gz-MSV hamster tumors consistently developed high titers of CF antibodies against the homologous Gz-MSV tumor antigens as well as against purified preparations of mouse leukemia viruses. The gs antisera from such hamsters were found to be as useful as the presently used M-MSV rat sera for the detection of the murine leukemia gs viral antigens and infectious virus by the COMUL test.

AB - The biologic and antigenic interactions of a new strain of mouse sarcoma virus, Gazdar MSV (Gz-MSV), with the heterologous hamster host are described. Hamster tumors as well as cell lines derived from hamster tumors contained noninfectious C-type virus particles. The species-specific gs-1 antigen of the murine leukemia viruses was detected in various hamster tumor and tissue culture preparations including preparations of purified virus. Hamsters bearing primary or transplanted Gz-MSV hamster tumors consistently developed high titers of CF antibodies against the homologous Gz-MSV tumor antigens as well as against purified preparations of mouse leukemia viruses. The gs antisera from such hamsters were found to be as useful as the presently used M-MSV rat sera for the detection of the murine leukemia gs viral antigens and infectious virus by the COMUL test.

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Gazdar Strain of Murine Sarcoma Virus. Biologic and Antigenic Interactions with the Heterologous Hamster Host

Abstract

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