gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein

Fu Xin Yu, Paul A. Johnston, Thomas C. Südhof, Helen L. Yin

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

The polymerization of actin filaments is involved in growth, movement, and cell division. It has been shown that actin polymerization is controlled by gelsolin, whose interactions with actin are activated by calcium ion (Ca2+) and inhibited by membrane polyphosphoinositides (PPI). A smaller Ca2+- and PPI-regulated protein, gCap39, which has 49% sequence identity with gelsolin, has been identified by cDNA cloning and protein purification. Like gelsolin, gCap39 binds to the fast-growing (+) end of actin filaments. However, gCap39 does not sever actin filaments and can respond to Ca2+ and PPI transients independently, under conditions in which gelsolin is ineffective. The coexistence of gCap39 with gelsolin should allow precise regulation of actin assembly at the leading edge of the cell.

Original languageEnglish (US)
Pages (from-to)1413-1415
Number of pages3
JournalScience
Volume250
Issue number4986
StatePublished - Dec 7 1990

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Actin Capping Proteins
Gelsolin
Phosphatidylinositol Phosphates
Ions
Calcium
Actin Cytoskeleton
Actins
Polymerization
Cell Division
Organism Cloning
Proteins
Complementary DNA
Membranes
Growth

ASJC Scopus subject areas

  • General

Cite this

Yu, F. X., Johnston, P. A., Südhof, T. C., & Yin, H. L. (1990). gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein. Science, 250(4986), 1413-1415.

gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein. / Yu, Fu Xin; Johnston, Paul A.; Südhof, Thomas C.; Yin, Helen L.

In: Science, Vol. 250, No. 4986, 07.12.1990, p. 1413-1415.

Research output: Contribution to journalArticle

Yu, FX, Johnston, PA, Südhof, TC & Yin, HL 1990, 'gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein', Science, vol. 250, no. 4986, pp. 1413-1415.
Yu FX, Johnston PA, Südhof TC, Yin HL. gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein. Science. 1990 Dec 7;250(4986):1413-1415.
Yu, Fu Xin ; Johnston, Paul A. ; Südhof, Thomas C. ; Yin, Helen L. / gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein. In: Science. 1990 ; Vol. 250, No. 4986. pp. 1413-1415.
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