GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses

Abhishek S. Kashyap, Laura Fernandez-Rodriguez, Yun Zhao, Gianni Monaco, Marcel P. Trefny, Naohiro Yoshida, Kea Martin, Ashwani Sharma, Natacha Olieric, Pankaj Shah, Michal Stanczak, Nicole Kirchhammer, Sung Moo Park, Sebastien Wieckowski, Heinz Laubli, Rachid Zagani, Benjamin Kasenda, Michel O. Steinmetz, Hans Christian Reinecker, Alfred Zippelius

Research output: Contribution to journalArticle

Abstract

Certain chemotherapeutics elicit potent anti-tumor immunity. Kashyap et al. demonstrate that microtubule-destabilizing chemotherapeutics induce maturation of dendritic cells through activation of microtubule-associated protein GEF-H1. This leads to effective priming of CD8 T cells against tumor antigens. GEF-H1 is critical for anti-tumor immunity of microtubule-targeting chemotherapy.

Original languageEnglish (US)
Pages (from-to)3367-3380.e8
JournalCell Reports
Volume28
Issue number13
DOIs
StatePublished - Sep 24 2019
Externally publishedYes

Keywords

  • ansamitocin-P3
  • chemotherapy
  • cross presentation
  • dendritic cells
  • GEF-H1
  • immunotherapy
  • JNK pathway
  • lfc
  • microtubule-targeting agents
  • plinabulin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Kashyap, A. S., Fernandez-Rodriguez, L., Zhao, Y., Monaco, G., Trefny, M. P., Yoshida, N., Martin, K., Sharma, A., Olieric, N., Shah, P., Stanczak, M., Kirchhammer, N., Park, S. M., Wieckowski, S., Laubli, H., Zagani, R., Kasenda, B., Steinmetz, M. O., Reinecker, H. C., & Zippelius, A. (2019). GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses. Cell Reports, 28(13), 3367-3380.e8. https://doi.org/10.1016/j.celrep.2019.08.057