Gender-specific metabolomics approach to kidney cancer

Stanisław Deja, Adam Litarski, Karolina Anna Mielko, Natalia Pudełko-Malik, Wojciech Wojtowicz, Adam Zabek, Tomasz Szydełko, Piotr Młynarz

Research output: Contribution to journalArticlepeer-review

Abstract

Renal cell carcinoma (RCC) is the most common form of kidney malignancy. RCC is more common among men with a 2/1 male/female incidence ratio worldwide. Given the underlying epidemiological differences in the RCC incidence between males and females, we explored the gender specific1H NMR serum metabolic profiles of RCC patients and their matched controls. A number of differential metabolites were shared by male and female RCC patients. These RCC specific changes included lower lactate, threonine, histidine, and choline levels together with increased levels of pyruvate, N-acetylated glycoproteins, beta-hydroxybutyrate, acetoacetate, and lysine. Additionally, serum lactate/pyruvate ratio was a strong predictor of RCC status regardless of gender. Although only moderate changes in metabolic profiles were observed between control males and females there were substantial gender related differences among RCC patients. Gender specific metabolic features associated with RCC status were identified suggesting that different metabolic panels could be leveraged for a more precise diagnostic.

Original languageEnglish (US)
Article number767
JournalMetabolites
Volume11
Issue number11
DOIs
StatePublished - Nov 2021

Keywords

  • Female
  • Gender
  • Male
  • Metabolomics
  • NMR
  • RCC
  • Renal cell carcinoma
  • Serum

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology

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