Gender-specific research for emergency diagnosis and management of ischemic heart disease

Proceedings from the 2014 academic emergency medicine consensus conference cardiovascular research workgroup

Basmah Safdar, John T. Nagurney, Ayodola Anise, Holli A. Devon, Gail D'Onofrio, Erik P. Hess, Judd E. Hollander, Mariane J. Legato, Alyson J. McGregor, Jane Scott, Semhar Tewelde, Deborah B. Diercks

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Coronary artery disease (CAD) is the most common cause of death for both men and women. However, over the years, emergency physicians, cardiologists, and other health care practitioners have observed varying outcomes in men and women with symptomatic CAD. Women in general are 10 to 15 years older than men when they develop CAD, but suffer worse postinfarction outcomes compared to age-matched men. This article was developed by the cardiovascular workgroup at the 2014 Academic Emergency Medicine (AEM) consensus conference to identify sex- and gender-specific gaps in the key themes and research questions related to emergency cardiac ischemia care. The workgroup had diverse stakeholder representation from emergency medicine, cardiology, critical care, nursing, emergency medical services, patients, and major policy-makers in government, academia, and patient care. We implemented the nominal group technique to identify and prioritize themes and research questions using electronic mail, monthly conference calls, in-person meetings, and Web-based surveys between June 2013 and May 2014. Through three rounds of nomination and refinement, followed by an in-person meeting on May 13, 2014, we achieved consensus on five priority themes and 30 research questions. The overarching themes were as follows: 1) the full spectrum of sex-specific risk as well as presentation of cardiac ischemia may not be captured by our standard definition of CAD and needs to incorporate other forms of ischemic heart disease (IHD); 2) diagnosis is further challenged by sex/gender differences in presentation and variable sensitivity of cardiac biomarkers, imaging, and risk scores; 3) sex-specific pathophysiology of cardiac ischemia extends beyond conventional obstructive CAD to include other causes such as microvascular dysfunction, takotsubo, and coronary artery dissection, better recognized as IHD; 4) treatment and prognosis are influenced by sex-specific variations in biology, as well as patient-provider communication; and 5) the changing definitions of pathophysiology call for looking beyond conventionally defined cardiovascular outcomes to patient-centered outcomes. These emergency care priorities should guide future clinical and basic science research and extramural funding in an area that greatly influences patient outcomes.

Original languageEnglish (US)
Pages (from-to)1350-1360
Number of pages11
JournalAcademic Emergency Medicine
Volume21
Issue number12
DOIs
StatePublished - Dec 1 2014

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Emergency Medicine
Myocardial Ischemia
Coronary Artery Disease
Consensus
Emergencies
Research
Ischemia
Emergency Medical Services
Critical Care Nursing
Cardiology
Administrative Personnel
Sex Characteristics
Dissection
Cause of Death
Coronary Vessels
Patient Care
Biomarkers
Communication
Delivery of Health Care
Physicians

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Gender-specific research for emergency diagnosis and management of ischemic heart disease : Proceedings from the 2014 academic emergency medicine consensus conference cardiovascular research workgroup. / Safdar, Basmah; Nagurney, John T.; Anise, Ayodola; Devon, Holli A.; D'Onofrio, Gail; Hess, Erik P.; Hollander, Judd E.; Legato, Mariane J.; McGregor, Alyson J.; Scott, Jane; Tewelde, Semhar; Diercks, Deborah B.

In: Academic Emergency Medicine, Vol. 21, No. 12, 01.12.2014, p. 1350-1360.

Research output: Contribution to journalArticle

Safdar, Basmah ; Nagurney, John T. ; Anise, Ayodola ; Devon, Holli A. ; D'Onofrio, Gail ; Hess, Erik P. ; Hollander, Judd E. ; Legato, Mariane J. ; McGregor, Alyson J. ; Scott, Jane ; Tewelde, Semhar ; Diercks, Deborah B. / Gender-specific research for emergency diagnosis and management of ischemic heart disease : Proceedings from the 2014 academic emergency medicine consensus conference cardiovascular research workgroup. In: Academic Emergency Medicine. 2014 ; Vol. 21, No. 12. pp. 1350-1360.
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