Gene complementing xeroderma pigmentosum group A cells maps to distal human chromosome 9q

Karla A. Henning, Roger A. Schultz, Gurbax S. Sekhon, Errol C. Friedberg

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Phenotypic complementation of xeroderma pigmentosum group A (XP-A) cells by microcell-mediated transfer of a single rearranged neo-tagged human chromosome from a human-mouse somatic cell hybrid designated K3SUB1A9-3 was reported previously. Extended growth of this human-mouse hybrid in culture led to deletion of the small arm of the human chromosome, with concomitant loss of complementing ability when introduced into XP-A cells by microcell-mediated chromosome transfer. Cytogenetic analysis of both hybrids suggests that the complementing locus is on chromosome 9q22.2-q34.3, and Southern blot analysis confirms the presence of distal chromosome 9q sequences.

Original languageEnglish (US)
Pages (from-to)395-400
Number of pages6
JournalSomatic Cell and Molecular Genetics
Volume16
Issue number4
DOIs
StatePublished - Jul 1 1990

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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