Gene complementing xeroderma pigmentosum group A cells maps to distal human chromosome 9q

Karla A. Henning, Roger A. Schultz, Gurbax S. Sekhon, Errol C. Friedberg

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Phenotypic complementation of xeroderma pigmentosum group A (XP-A) cells by microcell-mediated transfer of a single rearranged neo-tagged human chromosome from a human-mouse somatic cell hybrid designated K3SUB1A9-3 was reported previously. Extended growth of this human-mouse hybrid in culture led to deletion of the small arm of the human chromosome, with concomitant loss of complementing ability when introduced into XP-A cells by microcell-mediated chromosome transfer. Cytogenetic analysis of both hybrids suggests that the complementing locus is on chromosome 9q22.2-q34.3, and Southern blot analysis confirms the presence of distal chromosome 9q sequences.

Original languageEnglish (US)
Pages (from-to)395-400
Number of pages6
JournalSomatic Cell and Molecular Genetics
Volume16
Issue number4
DOIs
StatePublished - Jul 1990

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Xeroderma Pigmentosum
Human Chromosomes
Chromosomes
Genes
Hybrid Cells
Cytogenetic Analysis
Southern Blotting
Growth

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

Cite this

Gene complementing xeroderma pigmentosum group A cells maps to distal human chromosome 9q. / Henning, Karla A.; Schultz, Roger A.; Sekhon, Gurbax S.; Friedberg, Errol C.

In: Somatic Cell and Molecular Genetics, Vol. 16, No. 4, 07.1990, p. 395-400.

Research output: Contribution to journalArticle

Henning, Karla A. ; Schultz, Roger A. ; Sekhon, Gurbax S. ; Friedberg, Errol C. / Gene complementing xeroderma pigmentosum group A cells maps to distal human chromosome 9q. In: Somatic Cell and Molecular Genetics. 1990 ; Vol. 16, No. 4. pp. 395-400.
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