Gene Expression Analysis Identifies Cholesterol Metabolism Dysregulation in Hippocampus of Phenytoin-Resistant Pentylenetetrazol-Kindled Epileptic Mice

Sridhar Amalakanti, Unis Ahmad Bhat, Madhavi B. Mylavarapu, Nitin Khandelwal, N. V. Sundarachary, Sumana Chakravarty, Arvind Kumar

Research output: Contribution to journalArticlepeer-review

Abstract

Pharmaco-resistant Epilepsy has been a major challenge for medical interventions in controlling seizures. To date, up to 33% of the patients with epilepsy do not show adequate response to anti-epileptic drugs even after prolonged combinatorial drug usage. Using microarray, this study explores the changes in hippocampal gene expression in the phenytoin-resistant pentylenetetrazol (PTZ)-kindled mouse model of epilepsy. Our results from mRNA microarray analysis show distinct gene expression profiles in the hippocampus of phenytoin-resistant and sensitive mice. Pathway enrichment analysis showed differential expression of genes involved in cholesterol biosynthesis in phenytoin-resistant and sensitive mice.

Original languageEnglish (US)
Pages (from-to)485-490
Number of pages6
JournalNeuroMolecular Medicine
Volume23
Issue number4
DOIs
StatePublished - Dec 2021
Externally publishedYes

Keywords

  • Cholesterol
  • Convulsion
  • Drug-resistant epilepsy
  • Microarray
  • Neurological

ASJC Scopus subject areas

  • Molecular Medicine
  • Neurology
  • Cellular and Molecular Neuroscience

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