Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases

Lei Xu, Steven S. Shen, Yujin Hoshida, Aravind Subramanian, Ken Ross, Jean Philippe Brunet, Stephan N. Wagner, Sridhar Ramaswamy, Jill P. Mesirov, Richard O. Hynes

Research output: Contribution to journalArticlepeer-review

145 Scopus citations

Abstract

Metastasis is the deadliest phase of cancer progression. Experimental models using immunodeficient mice have been used to gain insights into the mechanisms of metastasis. We report here the identification of a "metastasis aggressiveness gene expression signature" derived using human melanoma cells selected based on their metastatic potentials in a xenotransplant metastasis model. Comparison with expression data from human melanoma patients shows that this metastasis gene signature correlates with the aggressiveness of melanoma metastases in human patients. Many genes encoding secreted and membrane proteins are included in the signature, suggesting the importance of tumor-microenvironment interactions during metastasis.

Original languageEnglish (US)
Pages (from-to)760-769
Number of pages10
JournalMolecular Cancer Research
Volume6
Issue number5
DOIs
StatePublished - May 1 2008

ASJC Scopus subject areas

  • Molecular Biology
  • Oncology
  • Cancer Research

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