Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies - Changes in drug metabolizing genes and potential mechanisms linked to kava toxicity

Lei Guo, Qiang Shi, Stacey Dial, Qingsu Xia, Nan Mei, Quan zhen Li, Po Chuen Chan, Peter Fu

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The association of kava products with liver-related health risks has prompted regulatory action in many countries. We used a genome-wide gene expression approach to generate global gene expression profiles from the livers of male B6C3F1 mice administered kava extract by gavage for 14 weeks, and identified the differentially expressed drug metabolizing genes in response to kava treatments. Analyses of gene functions and pathways reveal that the levels of significant numbers of genes involving drug metabolism were changed and that the pathways involving xenobiotics metabolism, Nrf2-mediated oxidative stress response, mitochondrial functions and others, were altered. Our results indicate that kava extract can significantly modulate drug metabolizing enzymes, potentially leading to herb-drug interactions and hepatotoxicity.

Original languageEnglish (US)
Pages (from-to)686-696
Number of pages11
JournalFood and Chemical Toxicology
Volume48
Issue number2
DOIs
StatePublished - Feb 1 2010

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Keywords

  • Drug metabolizing enzyme
  • Drug metabolizing gene
  • Gene expression
  • Kava extract
  • Microarray
  • TaqMan assay

ASJC Scopus subject areas

  • Food Science
  • Toxicology

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