Gene Expression Regulation

Chromatin Modification in the CNS

Jenny Hsieh, A. Tsai, K. Ure

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The cellular and molecular mechanisms that control neural stem cell lineage decisions during development and throughout adulthood remain a central challenge. Epigenetic mechanisms and chromatin remodeling have emerged to play fundamental roles in gene regulation. Studies have implicated chromatin structure as an active mediator underlying brain function, neural cell growth and differentiation, and plasticity. These epigenetic mechanisms include cell type-specific transcriptional regulators, histone modifications and chromatin remodeling enzymes, and small regulatory noncoding RNAs. Environmental signals that control growth and function in the brain act, at least in part, by interfacing with these diverse epigenetic mechanisms.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages611-617
Number of pages7
ISBN (Print)9780080450469
DOIs
StatePublished - 2010

Fingerprint

Gene Expression Regulation
Epigenomics
Chromatin
Chromatin Assembly and Disassembly
Histone Code
Small Untranslated RNA
Neural Stem Cells
Brain
Cell Lineage
Growth
Cell Differentiation
Enzymes
Genes

Keywords

  • Chromatin
  • Corepressor
  • Epigenetics
  • HDAC inhibitors
  • Histone deacetylase
  • MeCP2
  • MicroRNAs
  • Neural stem cell
  • Noncoding RNAs
  • Plasticity
  • Transcription

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hsieh, J., Tsai, A., & Ure, K. (2010). Gene Expression Regulation: Chromatin Modification in the CNS. In Encyclopedia of Neuroscience (pp. 611-617). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.00174-1

Gene Expression Regulation : Chromatin Modification in the CNS. / Hsieh, Jenny; Tsai, A.; Ure, K.

Encyclopedia of Neuroscience. Elsevier Ltd, 2010. p. 611-617.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hsieh, J, Tsai, A & Ure, K 2010, Gene Expression Regulation: Chromatin Modification in the CNS. in Encyclopedia of Neuroscience. Elsevier Ltd, pp. 611-617. https://doi.org/10.1016/B978-008045046-9.00174-1
Hsieh J, Tsai A, Ure K. Gene Expression Regulation: Chromatin Modification in the CNS. In Encyclopedia of Neuroscience. Elsevier Ltd. 2010. p. 611-617 https://doi.org/10.1016/B978-008045046-9.00174-1
Hsieh, Jenny ; Tsai, A. ; Ure, K. / Gene Expression Regulation : Chromatin Modification in the CNS. Encyclopedia of Neuroscience. Elsevier Ltd, 2010. pp. 611-617
@inbook{31838921eb15478492837fde745a43c3,
title = "Gene Expression Regulation: Chromatin Modification in the CNS",
abstract = "The cellular and molecular mechanisms that control neural stem cell lineage decisions during development and throughout adulthood remain a central challenge. Epigenetic mechanisms and chromatin remodeling have emerged to play fundamental roles in gene regulation. Studies have implicated chromatin structure as an active mediator underlying brain function, neural cell growth and differentiation, and plasticity. These epigenetic mechanisms include cell type-specific transcriptional regulators, histone modifications and chromatin remodeling enzymes, and small regulatory noncoding RNAs. Environmental signals that control growth and function in the brain act, at least in part, by interfacing with these diverse epigenetic mechanisms.",
keywords = "Chromatin, Corepressor, Epigenetics, HDAC inhibitors, Histone deacetylase, MeCP2, MicroRNAs, Neural stem cell, Noncoding RNAs, Plasticity, Transcription",
author = "Jenny Hsieh and A. Tsai and K. Ure",
year = "2010",
doi = "10.1016/B978-008045046-9.00174-1",
language = "English (US)",
isbn = "9780080450469",
pages = "611--617",
booktitle = "Encyclopedia of Neuroscience",
publisher = "Elsevier Ltd",

}

TY - CHAP

T1 - Gene Expression Regulation

T2 - Chromatin Modification in the CNS

AU - Hsieh, Jenny

AU - Tsai, A.

AU - Ure, K.

PY - 2010

Y1 - 2010

N2 - The cellular and molecular mechanisms that control neural stem cell lineage decisions during development and throughout adulthood remain a central challenge. Epigenetic mechanisms and chromatin remodeling have emerged to play fundamental roles in gene regulation. Studies have implicated chromatin structure as an active mediator underlying brain function, neural cell growth and differentiation, and plasticity. These epigenetic mechanisms include cell type-specific transcriptional regulators, histone modifications and chromatin remodeling enzymes, and small regulatory noncoding RNAs. Environmental signals that control growth and function in the brain act, at least in part, by interfacing with these diverse epigenetic mechanisms.

AB - The cellular and molecular mechanisms that control neural stem cell lineage decisions during development and throughout adulthood remain a central challenge. Epigenetic mechanisms and chromatin remodeling have emerged to play fundamental roles in gene regulation. Studies have implicated chromatin structure as an active mediator underlying brain function, neural cell growth and differentiation, and plasticity. These epigenetic mechanisms include cell type-specific transcriptional regulators, histone modifications and chromatin remodeling enzymes, and small regulatory noncoding RNAs. Environmental signals that control growth and function in the brain act, at least in part, by interfacing with these diverse epigenetic mechanisms.

KW - Chromatin

KW - Corepressor

KW - Epigenetics

KW - HDAC inhibitors

KW - Histone deacetylase

KW - MeCP2

KW - MicroRNAs

KW - Neural stem cell

KW - Noncoding RNAs

KW - Plasticity

KW - Transcription

UR - http://www.scopus.com/inward/record.url?scp=84882868299&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882868299&partnerID=8YFLogxK

U2 - 10.1016/B978-008045046-9.00174-1

DO - 10.1016/B978-008045046-9.00174-1

M3 - Chapter

SN - 9780080450469

SP - 611

EP - 617

BT - Encyclopedia of Neuroscience

PB - Elsevier Ltd

ER -