Gene Expression Regulation: Chromatin Modification in the CNS

Jenny Hsieh, A. Tsai, K. Ure

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The cellular and molecular mechanisms that control neural stem cell lineage decisions during development and throughout adulthood remain a central challenge. Epigenetic mechanisms and chromatin remodeling have emerged to play fundamental roles in gene regulation. Studies have implicated chromatin structure as an active mediator underlying brain function, neural cell growth and differentiation, and plasticity. These epigenetic mechanisms include cell type-specific transcriptional regulators, histone modifications and chromatin remodeling enzymes, and small regulatory noncoding RNAs. Environmental signals that control growth and function in the brain act, at least in part, by interfacing with these diverse epigenetic mechanisms.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages611-617
Number of pages7
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009

Keywords

  • Chromatin
  • Corepressor
  • Epigenetics
  • HDAC inhibitors
  • Histone deacetylase
  • MeCP2
  • MicroRNAs
  • Neural stem cell
  • Noncoding RNAs
  • Plasticity
  • Transcription

ASJC Scopus subject areas

  • Neuroscience(all)

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