Gene-expression signatures: Biomarkers toward diagnosing multiple sclerosis

J. T. Tossberg, P. S. Crooke, M. A. Henderson, S. Sriram, D. Mrelashvili, S. Chitnis, C. Polman, S. Vosslamber, C. L. Verweij, N. J. Olsen, T. M. Aune

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Identification of biomarkers contributing to disease diagnosis, classification or prognosis could be of considerable utility. For example, primary methods to diagnose multiple sclerosis (MS) include magnetic resonance imaging and detection of immunological abnormalities in cerebrospinal fluid. We determined whether gene-expression differences in blood discriminated MS subjects from comparator groups, and identified panels of ratios that performed with varying degrees of accuracy depending upon complexity of comparator groups. High levels of overall accuracy were achieved by comparing MS with homogeneous comparator groups. Overall accuracy was compromised when MS was compared with a heterogeneous comparator group. Results, validated in independent cohorts, indicate that gene-expression differences in blood accurately exclude or include a diagnosis of MS and suggest that these approaches may provide clinically useful prediction of MS.

Original languageEnglish (US)
Pages (from-to)146-154
Number of pages9
JournalGenes and Immunity
Volume13
Issue number2
DOIs
StatePublished - Feb 1 2012

Keywords

  • diagnosis
  • genomics
  • multiple sclerosis

ASJC Scopus subject areas

  • Immunology
  • Genetics
  • Genetics(clinical)

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    Tossberg, J. T., Crooke, P. S., Henderson, M. A., Sriram, S., Mrelashvili, D., Chitnis, S., Polman, C., Vosslamber, S., Verweij, C. L., Olsen, N. J., & Aune, T. M. (2012). Gene-expression signatures: Biomarkers toward diagnosing multiple sclerosis. Genes and Immunity, 13(2), 146-154. https://doi.org/10.1038/gene.2011.66