Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q

James Tomfohrde; Alan Silverman; Robert Barnes; Marcelo A. Fernandez-Vina; Melodie Young; Detra Lory; Laura Morris; Kirk D. Wuepper; Peter Stastny; Alan Menter; Anne Bowcock

doi:10.1126/science.8178173

Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q

James Tomfohrde, Alan Silverman, Robert Barnes, Marcelo A. Fernandez-Vina, Melodie Young, Detra Lory, Laura Morris, Kirk D. Wuepper, Peter Stastny, Alan Menter, Anne Bowcock

Internal Medicine

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Abstract

A gene involved in psoriasis susceptibility was localized to the distal region of human chromosome 17q as a result of a genome-wide linkage analysis with polymorphic microsatellites and eight multiply affected psoriasis kindreds. In the family which showed the strongest evidence for linkage, the recombination fraction between a psoriasis susceptibility locus and D17S784 was 0.04 with a maximum two-point lod score of 5.33. There was also evidence for genetic heterogeneity and although none of the linked families showed any association with HLA-Cw6, two unlinked families showed weak levels of association. This study demonstrates that in some families, psoriasis susceptibility is due to variation at a single major genetic locus other than the human lymphocyte antigen locus.

Original language	English (US)
Pages (from-to)	1141-1145
Number of pages	5
Journal	Science
Volume	264
Issue number	5162
DOIs	https://doi.org/10.1126/science.8178173
State	Published - May 20 1994

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title = "Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q",

abstract = "A gene involved in psoriasis susceptibility was localized to the distal region of human chromosome 17q as a result of a genome-wide linkage analysis with polymorphic microsatellites and eight multiply affected psoriasis kindreds. In the family which showed the strongest evidence for linkage, the recombination fraction between a psoriasis susceptibility locus and D17S784 was 0.04 with a maximum two-point lod score of 5.33. There was also evidence for genetic heterogeneity and although none of the linked families showed any association with HLA-Cw6, two unlinked families showed weak levels of association. This study demonstrates that in some families, psoriasis susceptibility is due to variation at a single major genetic locus other than the human lymphocyte antigen locus.",

author = "James Tomfohrde and Alan Silverman and Robert Barnes and Fernandez-Vina, {Marcelo A.} and Melodie Young and Detra Lory and Laura Morris and Wuepper, {Kirk D.} and Peter Stastny and Alan Menter and Anne Bowcock",

year = "1994",

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doi = "10.1126/science.8178173",

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volume = "264",

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T1 - Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q

AU - Tomfohrde, James

AU - Silverman, Alan

AU - Barnes, Robert

AU - Fernandez-Vina, Marcelo A.

AU - Young, Melodie

AU - Lory, Detra

AU - Morris, Laura

AU - Wuepper, Kirk D.

AU - Stastny, Peter

AU - Menter, Alan

AU - Bowcock, Anne

PY - 1994/5/20

Y1 - 1994/5/20

N2 - A gene involved in psoriasis susceptibility was localized to the distal region of human chromosome 17q as a result of a genome-wide linkage analysis with polymorphic microsatellites and eight multiply affected psoriasis kindreds. In the family which showed the strongest evidence for linkage, the recombination fraction between a psoriasis susceptibility locus and D17S784 was 0.04 with a maximum two-point lod score of 5.33. There was also evidence for genetic heterogeneity and although none of the linked families showed any association with HLA-Cw6, two unlinked families showed weak levels of association. This study demonstrates that in some families, psoriasis susceptibility is due to variation at a single major genetic locus other than the human lymphocyte antigen locus.

AB - A gene involved in psoriasis susceptibility was localized to the distal region of human chromosome 17q as a result of a genome-wide linkage analysis with polymorphic microsatellites and eight multiply affected psoriasis kindreds. In the family which showed the strongest evidence for linkage, the recombination fraction between a psoriasis susceptibility locus and D17S784 was 0.04 with a maximum two-point lod score of 5.33. There was also evidence for genetic heterogeneity and although none of the linked families showed any association with HLA-Cw6, two unlinked families showed weak levels of association. This study demonstrates that in some families, psoriasis susceptibility is due to variation at a single major genetic locus other than the human lymphocyte antigen locus.

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Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q

Abstract

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