Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q

James Tomfohrde, Alan Silverman, Robert Barnes, Marcelo A. Fernandez-Vina, Melodie Young, Detra Lory, Laura Morris, Kirk D. Wuepper, Peter Stastny, Alan Menter, Anne Bowcock

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Abstract

A gene involved in psoriasis susceptibility was localized to the distal region of human chromosome 17q as a result of a genome-wide linkage analysis with polymorphic microsatellites and eight multiply affected psoriasis kindreds. In the family which showed the strongest evidence for linkage, the recombination fraction between a psoriasis susceptibility locus and D17S784 was 0.04 with a maximum two-point lod score of 5.33. There was also evidence for genetic heterogeneity and although none of the linked families showed any association with HLA-Cw6, two unlinked families showed weak levels of association. This study demonstrates that in some families, psoriasis susceptibility is due to variation at a single major genetic locus other than the human lymphocyte antigen locus.

Original languageEnglish (US)
Pages (from-to)1141-1145
Number of pages5
JournalScience
Volume264
Issue number5162
DOIs
StatePublished - May 20 1994

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    Tomfohrde, J., Silverman, A., Barnes, R., Fernandez-Vina, M. A., Young, M., Lory, D., Morris, L., Wuepper, K. D., Stastny, P., Menter, A., & Bowcock, A. (1994). Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q. Science, 264(5162), 1141-1145. https://doi.org/10.1126/science.8178173