Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q

James Tomfohrde, Alan Silverman, Robert Barnes, Marcelo A. Fernandez-Vina, Melodie Young, Detra Lory, Laura Morris, Kirk D. Wuepper, Peter Stastny, Alan Menter, Anne Bowcock

Research output: Contribution to journalArticle

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Abstract

A gene involved in psoriasis susceptibility was localized to the distal region of human chromosome 17q as a result of a genome-wide linkage analysis with polymorphic microsatellites and eight multiply affected psoriasis kindreds. In the family which showed the strongest evidence for linkage, the recombination fraction between a psoriasis susceptibility locus and D17S784 was 0.04 with a maximum two-point lod score of 5.33. There was also evidence for genetic heterogeneity and although none of the linked families showed any association with HLA-Cw6, two unlinked families showed weak levels of association. This study demonstrates that in some families, psoriasis susceptibility is due to variation at a single major genetic locus other than the human lymphocyte antigen locus.

Original languageEnglish (US)
Pages (from-to)1141-1145
Number of pages5
JournalScience
Volume264
Issue number5162
StatePublished - May 20 1994

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Human Chromosomes
Psoriasis
Genes
Lod Score
Genetic Loci
Genetic Heterogeneity
Microsatellite Repeats
Genetic Recombination
Genome
Lymphocytes
Antigens

ASJC Scopus subject areas

  • General

Cite this

Tomfohrde, J., Silverman, A., Barnes, R., Fernandez-Vina, M. A., Young, M., Lory, D., ... Bowcock, A. (1994). Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q. Science, 264(5162), 1141-1145.

Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q. / Tomfohrde, James; Silverman, Alan; Barnes, Robert; Fernandez-Vina, Marcelo A.; Young, Melodie; Lory, Detra; Morris, Laura; Wuepper, Kirk D.; Stastny, Peter; Menter, Alan; Bowcock, Anne.

In: Science, Vol. 264, No. 5162, 20.05.1994, p. 1141-1145.

Research output: Contribution to journalArticle

Tomfohrde, J, Silverman, A, Barnes, R, Fernandez-Vina, MA, Young, M, Lory, D, Morris, L, Wuepper, KD, Stastny, P, Menter, A & Bowcock, A 1994, 'Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q', Science, vol. 264, no. 5162, pp. 1141-1145.
Tomfohrde J, Silverman A, Barnes R, Fernandez-Vina MA, Young M, Lory D et al. Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q. Science. 1994 May 20;264(5162):1141-1145.
Tomfohrde, James ; Silverman, Alan ; Barnes, Robert ; Fernandez-Vina, Marcelo A. ; Young, Melodie ; Lory, Detra ; Morris, Laura ; Wuepper, Kirk D. ; Stastny, Peter ; Menter, Alan ; Bowcock, Anne. / Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q. In: Science. 1994 ; Vol. 264, No. 5162. pp. 1141-1145.
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AU - Lory, Detra

AU - Morris, Laura

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