Gene knockdown of γ-glutamylcysteine synthetase by RNA_i in the parasitic protozoa Trypanosoma brucei demonstrates that it is an essential enzyme

Medicine & Life Sciences

• Glutamate-Cysteine Ligase 100%
• Buthionine Sulfoximine 99%
• Gene Knockdown Techniques 91%
• Trypanosoma brucei brucei 91%
• RNA Interference 67%
• Sulfhydryl Compounds 60%
• Cell Death 42%
• Enzymes 38%
• Spermidine 36%
• trypanothione 24%
• Adenosylmethionine Decarboxylase 23%
• Ornithine Decarboxylase 17%
• Enzyme Inhibitors 16%
• Cytotoxins 15%
• Tetracycline 14%
• Oxidation-Reduction 13%
• Parasites 11%
• Cell Culture Techniques 10%
• RNA 9%
• Peptides 8%
• Phenotype 8%
• Gene Expression 8%
• Cell Line 8%
• Proteins 5%

Chemical Compounds

• Parasitic 85%
• Cell Death 74%
• Thiol 59%
• Spermidine 43%
• Biosynthesis 29%
• Trypanothione 27%
• Ornithine 22%
• Cytotoxic Agent 21%
• Tetracycline 19%
• Cofactor 16%
• Pharmacological Metabolism 13%
• Metabolite 12%
• Peptide 10%
• Protein 7%