Gene regulatory networks in the evolution and development of the heart

Research output: Contribution to journalArticle

652 Citations (Scopus)

Abstract

The heart, an ancient organ and the first to form and function during embryogenesis, evolved by the addition of new structures and functions to a primitive pump. Heart development is controlled by an evolutionarily conserved network of transcription factors that connect signaling pathways with genes for muscle growth, patterning, and contractility. During evolution, this ancestral gene network was expanded through gene duplication and co-option of additional networks. Mutations in components of the cardiac gene network cause congenital heart disease, the most common human birth defect. The consequences of such mutations reveal the logic of organogenesis and the evolutionary origins of morphological complexity.

Original languageEnglish (US)
Pages (from-to)1922-1927
Number of pages6
JournalScience
Volume313
Issue number5795
DOIs
StatePublished - Sep 29 2006

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Gene Regulatory Networks
Mutation
Gene Duplication
Organogenesis
Embryonic Development
Heart Diseases
Transcription Factors
Muscles
Growth
Genes

ASJC Scopus subject areas

  • General

Cite this

Gene regulatory networks in the evolution and development of the heart. / Olson, Eric N.

In: Science, Vol. 313, No. 5795, 29.09.2006, p. 1922-1927.

Research output: Contribution to journalArticle

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