Gene targeting of presynaptic proteins in synaptic plasticity and memory: Across the great divide

Craig M. Powell

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The past few decades have seen an explosion in our understanding of the molecular basis of learning and memory. The majority of these studies in mammals focused on post-synaptic signal transduction cascades involved in post-synaptic long-lasting plasticity. Until recently, relatively little work examined the role of presynaptic proteins in learning and memory in complex systems. The synaptic cleft figuratively represents a "great divide" between our knowledge of post- versus presynaptic involvement in learning and memory. While great strides have been made in our understanding of presynaptic proteins, we know very little of how presynaptically expressed forms of short- and long-term plasticity participate in information processing and storage. The paucity of cognitive behavioral research in the area of presynaptic proteins, however, is in stark contrast to the plethora of information concerning presynaptic protein involvement in neurotransmitter release, in modulation of release, and in both short- and long-term forms of presynaptic plasticity. It is now of great interest to begin to link the extensive literature on presynaptic proteins and presynaptic plasticity to cognitive behavior. In the future there is great promise with these approaches for identifying new targets in the treatment of cognitive disorders. This review article briefly surveys current knowledge on the role of presynaptic proteins in learning and memory in mammals and suggests future directions in learning and memory research on the presynaptic rim of the "great divide."

Original languageEnglish (US)
Pages (from-to)2-15
Number of pages14
JournalNeurobiology of Learning and Memory
Volume85
Issue number1
DOIs
StatePublished - Jan 2006

Fingerprint

Neuronal Plasticity
Gene Targeting
Learning
Proteins
Mammals
Behavioral Research
Explosions
Information Storage and Retrieval
Automatic Data Processing
Neurotransmitter Agents
Signal Transduction
Research

Keywords

  • Behavior
  • Hippocampus
  • Learning and memory
  • Long-term potentiation
  • Mossy fiber
  • Plasticity
  • Presynaptic
  • Short-term plasticity
  • Synaptic vesicle

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

Gene targeting of presynaptic proteins in synaptic plasticity and memory : Across the great divide. / Powell, Craig M.

In: Neurobiology of Learning and Memory, Vol. 85, No. 1, 01.2006, p. 2-15.

Research output: Contribution to journalArticle

@article{73eda3e3889642ee9269dea1f06c64f1,
title = "Gene targeting of presynaptic proteins in synaptic plasticity and memory: Across the great divide",
abstract = "The past few decades have seen an explosion in our understanding of the molecular basis of learning and memory. The majority of these studies in mammals focused on post-synaptic signal transduction cascades involved in post-synaptic long-lasting plasticity. Until recently, relatively little work examined the role of presynaptic proteins in learning and memory in complex systems. The synaptic cleft figuratively represents a {"}great divide{"} between our knowledge of post- versus presynaptic involvement in learning and memory. While great strides have been made in our understanding of presynaptic proteins, we know very little of how presynaptically expressed forms of short- and long-term plasticity participate in information processing and storage. The paucity of cognitive behavioral research in the area of presynaptic proteins, however, is in stark contrast to the plethora of information concerning presynaptic protein involvement in neurotransmitter release, in modulation of release, and in both short- and long-term forms of presynaptic plasticity. It is now of great interest to begin to link the extensive literature on presynaptic proteins and presynaptic plasticity to cognitive behavior. In the future there is great promise with these approaches for identifying new targets in the treatment of cognitive disorders. This review article briefly surveys current knowledge on the role of presynaptic proteins in learning and memory in mammals and suggests future directions in learning and memory research on the presynaptic rim of the {"}great divide.{"}",
keywords = "Behavior, Hippocampus, Learning and memory, Long-term potentiation, Mossy fiber, Plasticity, Presynaptic, Short-term plasticity, Synaptic vesicle",
author = "Powell, {Craig M.}",
year = "2006",
month = "1",
doi = "10.1016/j.nlm.2005.08.014",
language = "English (US)",
volume = "85",
pages = "2--15",
journal = "Neurobiology of Learning and Memory",
issn = "1074-7427",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Gene targeting of presynaptic proteins in synaptic plasticity and memory

T2 - Across the great divide

AU - Powell, Craig M.

PY - 2006/1

Y1 - 2006/1

N2 - The past few decades have seen an explosion in our understanding of the molecular basis of learning and memory. The majority of these studies in mammals focused on post-synaptic signal transduction cascades involved in post-synaptic long-lasting plasticity. Until recently, relatively little work examined the role of presynaptic proteins in learning and memory in complex systems. The synaptic cleft figuratively represents a "great divide" between our knowledge of post- versus presynaptic involvement in learning and memory. While great strides have been made in our understanding of presynaptic proteins, we know very little of how presynaptically expressed forms of short- and long-term plasticity participate in information processing and storage. The paucity of cognitive behavioral research in the area of presynaptic proteins, however, is in stark contrast to the plethora of information concerning presynaptic protein involvement in neurotransmitter release, in modulation of release, and in both short- and long-term forms of presynaptic plasticity. It is now of great interest to begin to link the extensive literature on presynaptic proteins and presynaptic plasticity to cognitive behavior. In the future there is great promise with these approaches for identifying new targets in the treatment of cognitive disorders. This review article briefly surveys current knowledge on the role of presynaptic proteins in learning and memory in mammals and suggests future directions in learning and memory research on the presynaptic rim of the "great divide."

AB - The past few decades have seen an explosion in our understanding of the molecular basis of learning and memory. The majority of these studies in mammals focused on post-synaptic signal transduction cascades involved in post-synaptic long-lasting plasticity. Until recently, relatively little work examined the role of presynaptic proteins in learning and memory in complex systems. The synaptic cleft figuratively represents a "great divide" between our knowledge of post- versus presynaptic involvement in learning and memory. While great strides have been made in our understanding of presynaptic proteins, we know very little of how presynaptically expressed forms of short- and long-term plasticity participate in information processing and storage. The paucity of cognitive behavioral research in the area of presynaptic proteins, however, is in stark contrast to the plethora of information concerning presynaptic protein involvement in neurotransmitter release, in modulation of release, and in both short- and long-term forms of presynaptic plasticity. It is now of great interest to begin to link the extensive literature on presynaptic proteins and presynaptic plasticity to cognitive behavior. In the future there is great promise with these approaches for identifying new targets in the treatment of cognitive disorders. This review article briefly surveys current knowledge on the role of presynaptic proteins in learning and memory in mammals and suggests future directions in learning and memory research on the presynaptic rim of the "great divide."

KW - Behavior

KW - Hippocampus

KW - Learning and memory

KW - Long-term potentiation

KW - Mossy fiber

KW - Plasticity

KW - Presynaptic

KW - Short-term plasticity

KW - Synaptic vesicle

UR - http://www.scopus.com/inward/record.url?scp=28944444811&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28944444811&partnerID=8YFLogxK

U2 - 10.1016/j.nlm.2005.08.014

DO - 10.1016/j.nlm.2005.08.014

M3 - Article

C2 - 16230036

AN - SCOPUS:28944444811

VL - 85

SP - 2

EP - 15

JO - Neurobiology of Learning and Memory

JF - Neurobiology of Learning and Memory

SN - 1074-7427

IS - 1

ER -